CDC60/YPL160W Protein Information

Standard Name	Cdc60p 1
Systematic Name	Ypl160wp
ORF Classification	Verified
Description	Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA (2)
Name Description	Cell Division Cycle
Gene Product	LeuRS 2 , leucyl-tRNA synthetase 2

Experimental Data
Molecules/cell	158000 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,090
Molecular Weight (Da)	124,140
Isoelectric Point (pI)	5.68

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cdc60p (InterPro)
Physical Interactions	There are 29 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052EC7 \| P26637 MIPS: YPL160W NCBI: 135141 \| 1370340 \| 1403549 \| 3508 \| 6325097 \| NP_015165.1 GenBank/EMBL/DDBJ: DAA11274.1 \| X62878 \| X96770 \| Z73516
External Classifications	EC: 6.1.1.4 [Leucine--tRNA ligase]

Amino Acid Sequence (or in FASTA format)
1 MSSGLVLENT ARRDALIAIE KKYQKIWAEE HQFEIDAPSI EDEPITMDSE 51 ELHRTYPKFM SSMAYPYMNG VMHAGHCFTL SKVEFSIGFE RMNGKRALFP 101 LGFHCTGMPI LACADKLKRE AELFGKNFDN VPAEEEEIKE ETPAEKDHED 151 VTKFKAKKSK AAAKKGRGKY QFEIMLQLGI PREEIIKFAD AKYWLTYFPP 201 LCESDCTSLG ARIDWRRSFV TTDANPYYDA FIRWQMNKLK AAGKIKFGER 251 YTIYSEKDGQ ACMDHDRQSG EGVTPQEYIG VKIEALEFAD DAAKIIDSSS 301 DLDKSKKFYF VAATLRPETM YGQTCCFVSP TIEYGIFDAG DSYFITTERA 351 FKNMSYQKLT PKRGFYKPIV TVPGKAFIGT KIHAPQSVYP ELRILPMETV 401 IATKGTGVVT CVPSNSPDDY ITTKDLLHKP EYYGIKPEWI DHEIVPIMHT 451 EKYGDLTAKA IVEEKKIQSP KDKNLLAEAK KIAYKEDYYT GTMIYGPYKG 501 EKVEQAKNKV KADMIAAGEA FVYNEPESQV MSRSGDDCIV SLEDQWYVDY 551 GEESWKKQAI ECLEGMQLFA PEVKNAFEGV LDWLKNWAVC RTYGLGTRLP 601 WDEKYLVESL SDSTIYQSFY TIAHLLFKDY YGNEIGPLGI SADQMTDEVF 651 DYIFQHQDDV KNTNIPLPAL QKLRREFEYF YPLDVSISGK DLIPNHLTFF 701 IYTHVALFPK KFWPKGIRAN GHLMLNNSKM SKSTGNFMTL EQTVEKFGAD 751 AARIAFADAG DTVEDANFDE SNANAAILRL FNLKEWAEEI TKESNLRTGE 801 ITDFFDIAFE HEMNALIEKT YEQYALTNYK NALKYGLFDF QAARDYYREA 851 SGVMHKDLIA RYIETQALLL APIAPHFAEY IYREVLGNQT SVQNAKFPRA 901 SKPVDKGVLA ALDYLRNLQR SIREGEGQAL KKKKGKSAEI DASKPVKLTL 951 LISESFPEWQ SQCVEIVRKL FSEQTLDDNK KVREHIEPKE MKRAMPFISL 1001 LKQRLANEKP EDVFERELQF SEIDTVKAAA RNVKKAAQAL KIAEFSAISF 1051 PYGAKTGKDI FTGEEVEIPP VTKIVENAVP GNPGVVFQNI *

Amino Acid Sequence (or in FASTA format)

       1  MSSGLVLENT ARRDALIAIE KKYQKIWAEE HQFEIDAPSI EDEPITMDSE
      51  ELHRTYPKFM SSMAYPYMNG VMHAGHCFTL SKVEFSIGFE RMNGKRALFP
     101  LGFHCTGMPI LACADKLKRE AELFGKNFDN VPAEEEEIKE ETPAEKDHED
     151  VTKFKAKKSK AAAKKGRGKY QFEIMLQLGI PREEIIKFAD AKYWLTYFPP
     201  LCESDCTSLG ARIDWRRSFV TTDANPYYDA FIRWQMNKLK AAGKIKFGER
     251  YTIYSEKDGQ ACMDHDRQSG EGVTPQEYIG VKIEALEFAD DAAKIIDSSS
     301  DLDKSKKFYF VAATLRPETM YGQTCCFVSP TIEYGIFDAG DSYFITTERA
     351  FKNMSYQKLT PKRGFYKPIV TVPGKAFIGT KIHAPQSVYP ELRILPMETV
     401  IATKGTGVVT CVPSNSPDDY ITTKDLLHKP EYYGIKPEWI DHEIVPIMHT
     451  EKYGDLTAKA IVEEKKIQSP KDKNLLAEAK KIAYKEDYYT GTMIYGPYKG
     501  EKVEQAKNKV KADMIAAGEA FVYNEPESQV MSRSGDDCIV SLEDQWYVDY
     551  GEESWKKQAI ECLEGMQLFA PEVKNAFEGV LDWLKNWAVC RTYGLGTRLP
     601  WDEKYLVESL SDSTIYQSFY TIAHLLFKDY YGNEIGPLGI SADQMTDEVF
     651  DYIFQHQDDV KNTNIPLPAL QKLRREFEYF YPLDVSISGK DLIPNHLTFF
     701  IYTHVALFPK KFWPKGIRAN GHLMLNNSKM SKSTGNFMTL EQTVEKFGAD
     751  AARIAFADAG DTVEDANFDE SNANAAILRL FNLKEWAEEI TKESNLRTGE
     801  ITDFFDIAFE HEMNALIEKT YEQYALTNYK NALKYGLFDF QAARDYYREA
     851  SGVMHKDLIA RYIETQALLL APIAPHFAEY IYREVLGNQT SVQNAKFPRA
     901  SKPVDKGVLA ALDYLRNLQR SIREGEGQAL KKKKGKSAEI DASKPVKLTL
     951  LISESFPEWQ SQCVEIVRKL FSEQTLDDNK KVREHIEPKE MKRAMPFISL
    1001  LKQRLANEKP EDVFERELQF SEIDTVKAAA RNVKKAAQAL KIAEFSAISF
    1051  PYGAKTGKDI FTGEEVEIPP VTKIVENAVP GNPGVVFQNI *

external links for Cdc60p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Cdc60p

1)	Bedard DP, et al. (1981) New mutations in the yeast Saccharomyces cerevisiae affecting completion of Start. Curr Genet 4:205-214
2)	Hohmann S and Thevelein JM (1992) The cell division cycle gene CDC60 encodes cytosolic leucyl-tRNA synthetase in Saccharomyces cerevisiae. Gene 120(1):43-9
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41