KIP2/YPL155C Protein Information

Standard Name	Kip2p 1
Systematic Name	Ypl155cp
ORF Classification	Verified
Description	Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle (2, 3)
Name Description	KInesin related Protein 1

Experimental Data
Molecules/cell	656 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	706
Molecular Weight (Da)	78,377
Isoelectric Point (pI)	10.2

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Kip2p (InterPro)
Physical Interactions	There are 14 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012DE72 \| P28743 MIPS: YPL155C NCBI: 125418 \| 1370330 \| 1403554 \| 3854 \| 6325102 \| NP_015170.1 GenBank/EMBL/DDBJ: DAA11279.1 \| X96770 \| Z11963 \| Z73511

Amino Acid Sequence (or in FASTA format)
1 MIQKMSPSLR RPSTRSSSGS SNIPQSPSVR STSSFSNLTR NSIRSTSNSG 51 SQSISASSTR SNSPLRSVSA KSDPFLHPGR IRIRRSDSIN NNSRKNDTYT 101 GSITVTIRPK PRSVGTSRDH VGLKSPRYSQ PRSNSHHGSN TFVRDPWFIT 151 NDKTIVHEEI GEFKFDHVFA SHCTNLEVYE RTSKPMIDKL LMGFNATIFA 201 YGMTGSGKTF TMSGNEQELG LIPLSVSYLF TNIMEQSMNG DKKFDVIISY 251 LEIYNERIYD LLESGLEESG SRISTPSRLY MSKSNSNGLG VELKIRDDSQ 301 YGVKVIGLTE RRCESSEELL RWIAVGDKSR KIGETDYNAR SSRSHAIVLI 351 RLTSTNVKNG TSRSSTLSLC DLAGSERATG QQERRKEGSF INKSLLALGT 401 VISKLSADKM NSVGSNIPSP SASGSSSSSG NATNNGTSPS NHIPYRDSKL 451 TRLLQPALSG DSIVTTICTV DTRNDAAAET MNTLRFASRA KNVALHVSKK 501 SIISNGNNDG DKDRTIELLR RQLEEQRRMI SELKNRSNIG EPLTKSSNES 551 TYKDIKATGN DGDPNLALMR AENRVLKYKL ENCEKLLDKD VVDLQDSEIM 601 EIVEMLPFEV GTLLETKFQG LESQIRQYRK YTQKLEDKIM ALEKSGHTAM 651 SLTGCDGTEV IELQKMLERK DKMIEALQSA KRLRDRALKP LINTQQSPHP 701 VVDNDK*

Amino Acid Sequence (or in FASTA format)

       1  MIQKMSPSLR RPSTRSSSGS SNIPQSPSVR STSSFSNLTR NSIRSTSNSG
      51  SQSISASSTR SNSPLRSVSA KSDPFLHPGR IRIRRSDSIN NNSRKNDTYT
     101  GSITVTIRPK PRSVGTSRDH VGLKSPRYSQ PRSNSHHGSN TFVRDPWFIT
     151  NDKTIVHEEI GEFKFDHVFA SHCTNLEVYE RTSKPMIDKL LMGFNATIFA
     201  YGMTGSGKTF TMSGNEQELG LIPLSVSYLF TNIMEQSMNG DKKFDVIISY
     251  LEIYNERIYD LLESGLEESG SRISTPSRLY MSKSNSNGLG VELKIRDDSQ
     301  YGVKVIGLTE RRCESSEELL RWIAVGDKSR KIGETDYNAR SSRSHAIVLI
     351  RLTSTNVKNG TSRSSTLSLC DLAGSERATG QQERRKEGSF INKSLLALGT
     401  VISKLSADKM NSVGSNIPSP SASGSSSSSG NATNNGTSPS NHIPYRDSKL
     451  TRLLQPALSG DSIVTTICTV DTRNDAAAET MNTLRFASRA KNVALHVSKK
     501  SIISNGNNDG DKDRTIELLR RQLEEQRRMI SELKNRSNIG EPLTKSSNES
     551  TYKDIKATGN DGDPNLALMR AENRVLKYKL ENCEKLLDKD VVDLQDSEIM
     601  EIVEMLPFEV GTLLETKFQG LESQIRQYRK YTQKLEDKIM ALEKSGHTAM
     651  SLTGCDGTEV IELQKMLERK DKMIEALQSA KRLRDRALKP LINTQQSPHP
     701  VVDNDK*

external links for Kip2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Kip2p

1)	Roof DM, et al. (1992) Kinesin-related proteins required for assembly of the mitotic spindle. J Cell Biol 118(1):95-108
2)	Cottingham FR and Hoyt MA (1997) Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. J Cell Biol 138(5):1041-53
3)	Carvalho P, et al. (2004) Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation. Dev Cell 6(6):815-29
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41