PXA1/YPL147W Protein Information

Standard Name	Pxa1p 1
Systematic Name	Ypl147wp
Alias	Lpi1p , Pal1p 2 , Pat2p , Ssh2p
ORF Classification	Verified
Description	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder (1, 3, 4, 5)
Name Description	PeroXisomal ABC-transporter 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	870
Molecular Weight (Da)	100,024
Isoelectric Point (pI)	10.34

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pxa1p (InterPro)
Transmembrane Domains	There are 3 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 14 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000168427 \| P41909 MIPS: YPL147W NCBI: 1063413 \| 114152863 \| 1171992 \| 1244770 \| 1370314 \| 1403562 \| 2326833 \| 619668 \| 6325110 \| NP_015178.1 GenBank/EMBL/DDBJ: DAA11288.1 \| L38491 \| U17065 \| U43703 \| X96770 \| Z73502 \| Z73503
External Classifications	TC: 3.A.1.203 [The Peroxysomal Fatty Acyl CoA Transporter (P-FAT) Family]

Amino Acid Sequence (or in FASTA format)
1 MSTTLAAPAK LKSLLLNLHT HCIGLHVNDV TPKVYFKLLI RHLLQISRSN 51 AAHPKLRRRA QILLVSLFLS GVTLFSGVTY STFKIILKCY KFYKFPWKRR 101 NRRPLIRRTR SQMQLDSGAR IMYIPEVELV DRQSPDDNKF MNATDKKKRK 151 RIFIPPKDND VYEHDKFLFK NVELERAKNS QLFYSKFLNQ MNVLSKILIP 201 TVFDKNFLLL TAQIFFLVMR TWLSLFVAKL DGQIVKNIIA GRGRSFLWDL 251 GCWFLIAVPA SYTNSAIKLL QRKLSLNFRV NLTRYIHDMY LDKRLTFYKL 301 IFDAKASNSV IKNIDNSITN DVAKFCDATC SVFANIAKPV IDLIFFSVYL 351 RDNLGTVGVA GIFVNYFITG FILRKYTPPL GKLAGERSAS DGDYYNYHLN 401 MINNSEEIAF YQGTAVERTK VKELYDVLME KMLLVDKVKF GYNMLEDYVL 451 KYTWSGLGYV FASIPIVMST LATGINSEEK NMKEFIVNKR LMLSLADAGS 501 RLMHSIKDIS QLTGYTNRIF TLLSVLHRVH SLNFNYGAVP SILSIRTEDA 551 SRNSNLLPTT DNSQDAIRGT IQRNFNGIRL ENIDVIIPSV RASEGIKLIN 601 KLTFQIPLHI DPITSKSNSI QDLSKANDIK LPFLQGSGSS LLILGPNGCG 651 KSSIQRIIAE IWPVYNKNGL LSIPSENNIF FIPQKPYFSR GGTLRDQIIY 701 PMSSDEFFDR GFRDKELVQI LVEVKLDYLL KRGVGLTYLD AIADWKDLLS 751 GGEKQRVNFA RIMFHKPLYV VLDEATNAIS VDMEDYLFNL LKRYRFNFIS 801 ISQRPTLIKY HEMLLEIGEN RDGKWQLQAV GTDEAITSID NEIEELERKL 851 ERVKGWEDER TKLREKLEII *

Amino Acid Sequence (or in FASTA format)

       1  MSTTLAAPAK LKSLLLNLHT HCIGLHVNDV TPKVYFKLLI RHLLQISRSN
      51  AAHPKLRRRA QILLVSLFLS GVTLFSGVTY STFKIILKCY KFYKFPWKRR
     101  NRRPLIRRTR SQMQLDSGAR IMYIPEVELV DRQSPDDNKF MNATDKKKRK
     151  RIFIPPKDND VYEHDKFLFK NVELERAKNS QLFYSKFLNQ MNVLSKILIP
     201  TVFDKNFLLL TAQIFFLVMR TWLSLFVAKL DGQIVKNIIA GRGRSFLWDL
     251  GCWFLIAVPA SYTNSAIKLL QRKLSLNFRV NLTRYIHDMY LDKRLTFYKL
     301  IFDAKASNSV IKNIDNSITN DVAKFCDATC SVFANIAKPV IDLIFFSVYL
     351  RDNLGTVGVA GIFVNYFITG FILRKYTPPL GKLAGERSAS DGDYYNYHLN
     401  MINNSEEIAF YQGTAVERTK VKELYDVLME KMLLVDKVKF GYNMLEDYVL
     451  KYTWSGLGYV FASIPIVMST LATGINSEEK NMKEFIVNKR LMLSLADAGS
     501  RLMHSIKDIS QLTGYTNRIF TLLSVLHRVH SLNFNYGAVP SILSIRTEDA
     551  SRNSNLLPTT DNSQDAIRGT IQRNFNGIRL ENIDVIIPSV RASEGIKLIN
     601  KLTFQIPLHI DPITSKSNSI QDLSKANDIK LPFLQGSGSS LLILGPNGCG
     651  KSSIQRIIAE IWPVYNKNGL LSIPSENNIF FIPQKPYFSR GGTLRDQIIY
     701  PMSSDEFFDR GFRDKELVQI LVEVKLDYLL KRGVGLTYLD AIADWKDLLS
     751  GGEKQRVNFA RIMFHKPLYV VLDEATNAIS VDMEDYLFNL LKRYRFNFIS
     801  ISQRPTLIKY HEMLLEIGEN RDGKWQLQAV GTDEAITSID NEIEELERKL
     851  ERVKGWEDER TKLREKLEII *

external links for Pxa1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	TCDB
YGOB	DIP	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Pxa1p

1)	Shani N, et al. (1995) PXA1, a possible Saccharomyces cerevisiae ortholog of the human adrenoleukodystrophy gene. Proc Natl Acad Sci U S A 92(13):6012-6
2)	Swartzman EE, et al. (1996) The PAL1 gene product is a peroxisomal ATP-binding cassette transporter in the yeast Saccharomyces cerevisiae. J Cell Biol 132(4):549-63
3)	Shani N, et al. (1996) An S. cerevisiae peroxisomal transporter, orthologous to the human adrenoleukodystrophy protein, appears to be a heterodimer of two half ABC transporters: Pxa1p and Pxa2p. Ann N Y Acad Sci 804:770-2
4)	Hettema EH, et al. (1996) The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae. EMBO J 15(15):3813-22
5)	Shani N and Valle D (1996) A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters. Proc Natl Acad Sci U S A 93(21):11901-6