FRK1/YPL141C Protein Information Help

Standard Name Frk1p 1
Systematic Name Ypl141cp
ORF Classification Verified
Description Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Fatty acyl-CoA synthetase and RNA processing-associated Kinase 1
Experimental Data
Molecules/cell 556 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 865
Molecular Weight (Da) 97,692
Isoelectric Point (pI) 10.27

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Frk1p (InterPro)
Physical Interactions There are 104 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006964F | Q03002
MIPS: YPL141C
NCBI: 1244774 | 6325116 | 74676331 | NP_015184.1
GenBank/EMBL/DDBJ: DAA11293.1 | U43703
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSYTNKRHTY YGGFTNDLSD TFQYPQRTDE QRRKHVTFGP YILGSTLGEG
      51  EFGKVKLGWP KNFSNSSNST FDFPKQVAIK LIKRDSISND YRKEVKIYRE
     101  INALKHLSHP NIVKLEEVLQ NSRYIGIVLE YACGGEFYKY IQKKRRLKEM
     151  NACRLFSQLI SGVHYIHSKG LVHRDLKLEN LLLDKNENLV ITDFGFVNEF
     201  CSRNELMKTS CGSPCYAAPE LVISAEPYEA RKADIWSCGV ILYAILAGYL
     251  PWDDDPNNPE GSDIGRLYNY INSTPLKFPD YILPIPRDLL RRMLVSDPKK
     301  RINLKQIKKH EWLKPHSSFL SITPDEWDKL NNTQSVFRLA KPRRRYGSRP
     351  QSSCSTSSLG SRSDKRDSLV IDSTLITFPA PPQESQNHII TRPASIASDQ
     401  RLSPIRRSNR HNRSNSAASV ALQAVVNADR EYVLSHEQSL SPVQNIRQTT
     451  GNMTASLSPP PAISPGDIII ETTPIKRNTI SGSSIVPSLE EESSTTMQTS
     501  KIQPNNMASS QNHQYNKNKT QNSLQSAKNF YRTSSSSHTK PRPTSYHPGS
     551  YTTPPYNSNT LSIYEINEKA KSSASSQTLN QRDTSPFDST PYLALDTCIT
     601  SSSSIESSPK LITHGQFSVA KPSVDLQSVS GDLIKYKRDA DVVTRIYDEK
     651  YKQKRKSLRY SGIFSDISCD TVTEESDELR PPESPLQQHE GQESIDKAKT
     701  EDTSEKGSKS SNIAKATAQK HVNNHLERSL NEAESTKKRF SFLSLYSYDT
     751  SKSSLYSSMD SKRKPSPPSQ RRPKKDDSYQ TNSKNHYITA SNMQTSHQVS
     801  KDLPAPTMVQ NKCTLETKKA VRSNRSSIMV SEVNKASVDN KAAQSPEHST
     851  AKRVLGFFKR RSMKI*

external links for Frk1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Frk1p
1) Breitkreutz A, et al.  (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328(5981):1043-6
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) D'Aquino KE, et al.  (2005) The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell 19(2):223-34
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41