MKK2/YPL140C Protein Information Help

Standard Name Mkk2p 1
Systematic Name Ypl140cp
Alias Lpi6p , Ssp33p
ORF Classification Verified
Description MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Mitogen-activated Kinase Kinase 1
Experimental Data
Molecules/cell 1950 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 506
Molecular Weight (Da) 56,757
Isoelectric Point (pI) 9.1

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mkk2p (InterPro)
Physical Interactions There are 41 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F198 | P32491
MIPS: YPL140C
NCBI: 1244775 | 1709042 | 1781366 | 218443 | 6325117 | NP_015185.1
GenBank/EMBL/DDBJ: DAA11294.1 | D13785 | U10280 | U43703
External Classifications EC: 2.7.12.2 [Mitogen-activated protein kinase kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MASMFRPPES NRSHQKTPKL TLPVNLVQNA KSTNDGQHLN RSPYSSVNES
      51  PYSNNSTSAT STTSSMASNS TLLYNRSSTT TIKNRPVPPP LPPLVLTQKK
     101  DGIEYRVAGD SQLSERFSNL HVDITYKELL SSAPISTKLS NIDTTFIKKD
     151  LDTPEGEDSY PSTLLSAYDF SSSGSNSAPL SANNIISCSN LIQGKDVDQL
     201  EEEAWRFGHL KDEITTLGIL GEGAGGSVAK CRLKNGKKVF ALKTINTMNT
     251  DPEYQKQIFR ELQFNKSFKS DYIVQYYGMF TDEQSSSIYI AMEYMGGKSL
     301  EATYKNLLKR GGRISERVIG KIAESVLRGL SYLHERKVIH RDIKPQNILL
     351  NEKGEIKLCD FGVSGEAVNS LAMTFTGTSF YMAPERIQGQ PYSVTCDVWS
     401  LGLTLLEVAG GRFPFESDKI TQNVAPIELL TMILTFSPQL KDEPELDISW
     451  SKTFRSFIDY CLKKDARERP SPRQMLKHPW IVGQMKKKVN MERFVKKCWE
     501  KEKDGI*

external links for Mkk2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Mkk2p
1) Irie K, et al.  (1993) MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Mol Cell Biol 13(5):3076-83
2) Levin DE, et al.  (1994) Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae. Cell Mol Biol Res 40(3):229-39
3) Heinisch JJ, et al.  (1999) The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae. Mol Microbiol 32(4):671-80
4) Soler M, et al.  (1995) Characterization of domains in the yeast MAP kinase Slt2 (Mpk1) required for functional activity and in vivo interaction with protein kinases Mkk1 and Mkk2. Mol Microbiol 17(5):833-42
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41