RDS2/YPL133C Protein Information

Standard Name	Rds2p 1
Systematic Name	Ypl133cp
ORF Classification	Verified
Description	Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole (1, 2, 3)
Name Description	Regulator of Drug Sensitivity 1

Experimental Data
Molecules/cell	799 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	446
Molecular Weight (Da)	50,081
Isoelectric Point (pI)	7.63

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rds2p (InterPro)
Physical Interactions	There are 26 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BD29 \| P19541 MIPS: YPL133C NCBI: 1244781 \| 1730882 \| 3566 \| 51013787 \| 6325124 \| NP_015192.1 GenBank/EMBL/DDBJ: DAA11300.1 \| AY693168 \| U43703 \| X55731

Amino Acid Sequence (or in FASTA format)
1 MSANSGVKRA SKAFKTCLFC KRSHVVCDKQ RPCSRCVKRD IAHLCREDDI 51 AVPNEMPSQH ESSPNDNNIQ GKYANKAHTG IPSDYQNEPV NKSGSTYGEE 101 LSPKLDSSLV NDTTSLLLPQ QPVFVSENVG SEFSSLNEFL SMLENPLLTQ 151 TSLSSSSASN VHLENGSQTT QSPLEYQNDN RRDEIGVARQ ENRSPTIMSG 201 SSNSISKGDK QDQEKEESRI LANANENSAP TPKEQFFLTA ADPSTEMTPE 251 HRLKLVINAK LEAGLLKPYN YAKGYARLQD YMDKYMNQSS KQRILKPLST 301 IRPAFRTIAR SLKDVDLVLV EESFERMLLS YDRVFTSMSM PACLCRRTGE 351 IYRANKEFAS LVDCTVDDLR DGKLAIYELM TEESAVNFWE KYGSIAFDKG 401 QKAVLTSCSL RTKDGIRKRP CCFSFTIRRD RYNIPICIVG NFIPLS*

Amino Acid Sequence (or in FASTA format)

       1  MSANSGVKRA SKAFKTCLFC KRSHVVCDKQ RPCSRCVKRD IAHLCREDDI
      51  AVPNEMPSQH ESSPNDNNIQ GKYANKAHTG IPSDYQNEPV NKSGSTYGEE
     101  LSPKLDSSLV NDTTSLLLPQ QPVFVSENVG SEFSSLNEFL SMLENPLLTQ
     151  TSLSSSSASN VHLENGSQTT QSPLEYQNDN RRDEIGVARQ ENRSPTIMSG
     201  SSNSISKGDK QDQEKEESRI LANANENSAP TPKEQFFLTA ADPSTEMTPE
     251  HRLKLVINAK LEAGLLKPYN YAKGYARLQD YMDKYMNQSS KQRILKPLST
     301  IRPAFRTIAR SLKDVDLVLV EESFERMLLS YDRVFTSMSM PACLCRRTGE
     351  IYRANKEFAS LVDCTVDDLR DGKLAIYELM TEESAVNFWE KYGSIAFDKG
     401  QKAVLTSCSL RTKDGIRKRP CCFSFTIRRD RYNIPICIVG NFIPLS*

external links for Rds2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rds2p

1)	Akache B and Turcotte B (2002) New regulators of drug sensitivity in the family of yeast zinc cluster proteins. J Biol Chem 277(24):21254-60
2)	Soontorngun N, et al. (2007) Regulation of Gluconeogenesis in Saccharomyces cerevisiae Is Mediated by Activator and Repressor Functions of Rds2. Mol Cell Biol 27(22):7895-905
3)	Turcotte B, et al. (2010) Transcriptional regulation of nonfermentable carbon utilization in budding yeast. FEMS Yeast Res 10(1):2-13
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41