COX11/YPL132W Protein Information

Standard Name	Cox11p
Systematic Name	Ypl132wp
Alias	Lpi13p , Pso7p 1
ORF Classification	Verified
Description	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p (2, 3, 4)
Name Description	Cytochrome c OXidase

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	300
Molecular Weight (Da)	34,044
Isoelectric Point (pI)	8.89

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cox11p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 10 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012818D \| P19516 MIPS: YPL132W NCBI: 1244782 \| 1706080 \| 173234 \| 3567 \| 6325125 \| NP_015193.1 \| NM_001183946.1 GenBank/EMBL/DDBJ: DAA11301.1 \| M94864 \| U43703 \| X55731

Amino Acid Sequence (or in FASTA format)
1 MIRICPIVRS KVPLLGTFLR SDSWLAPHAL ALRRAICKNV ALRSYSVNSE 51 QPKHTFDISK LTRNEIQQLR ELKRARERKF KDRTVAFYFS SVAVLFLGLA 101 YAAVPLYRAI CARTGFGGIP ITDRRKFTDD KLIPVDTEKR IRISFTSEVS 151 QILPWKFVPQ QREVYVLPGE TALAFYKAKN YSDKDIIGMA TYSIAPGEAA 201 QYFNKIQCFC FEEQKLAAGE EIDMPVFFFI DPDFASDPAM RNIDDIILHY 251 TFFRAHYGDG TAVSDSKKEP EMNADEKAAS LANAAILSPE VIDTRKDNSN 301 *

Amino Acid Sequence (or in FASTA format)

       1  MIRICPIVRS KVPLLGTFLR SDSWLAPHAL ALRRAICKNV ALRSYSVNSE
      51  QPKHTFDISK LTRNEIQQLR ELKRARERKF KDRTVAFYFS SVAVLFLGLA
     101  YAAVPLYRAI CARTGFGGIP ITDRRKFTDD KLIPVDTEKR IRISFTSEVS
     151  QILPWKFVPQ QREVYVLPGE TALAFYKAKN YSDKDIIGMA TYSIAPGEAA
     201  QYFNKIQCFC FEEQKLAAGE EIDMPVFFFI DPDFASDPAM RNIDDIILHY
     251  TFFRAHYGDG TAVSDSKKEP EMNADEKAAS LANAAILSPE VIDTRKDNSN
     301  *

external links for Cox11p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Cox11p

1)	Brendel M and Henriques JA (2001) The pso mutants of Saccharomyces cerevisiae comprise two groups: one deficient in DNA repair and another with altered mutagen metabolism. Mutat Res 489(1):79-96
2)	Tzagoloff A, et al. (1990) Cytochrome oxidase assembly in yeast requires the product of COX11, a homolog of the P. denitrificans protein encoded by ORF3. EMBO J 9(9):2759-64
3)	Hiser L, et al. (2000) Cox11p is required for stable formation of the Cu(B) and magnesium centers of cytochrome c oxidase. J Biol Chem 275(1):619-23
4)	Khalimonchuk O, et al. (2005) Evidence for the association of yeast mitochondrial ribosomes with Cox11p, a protein required for the Cu(B) site formation of cytochrome c oxidase. Curr Genet 47(4):223-33