RPL5/YPL131W Protein Information

Standard Name	Rpl5p
Systematic Name	Ypl131wp
Alias	Lpi14p , Rpl1p
ORF Classification	Verified
Description	Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly (1, 2, 3, 4, 5, 6)
Name Description	Ribosomal Protein of the Large subunit
Gene Product	L18 6 , L1a 4 , L5 4 , YL3 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	297
Molecular Weight (Da)	33,714
Isoelectric Point (pI)	6.82

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rpl5p (InterPro)
Physical Interactions	There are 203 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000168429 \| P26321 MIPS: YPL131W NCBI: 1244783 \| 133003 \| 172424 \| 173232 \| 173235 \| 308153666 \| 315113347 \| 315113530 \| 315113575 \| 365767255 \| 365767296 \| 410562482 \| 49258843 \| 6325126 \| NP_015194.1 GenBank/EMBL/DDBJ: DAA11302.1 \| L01796 \| M65056 \| M94864 \| U43703

Amino Acid Sequence (or in FASTA format)
1 MAFQKDAKSS AYSSRFQTPF RRRREGKTDY YQRKRLVTQH KAKYNTPKYR 51 LVVRFTNKDI ICQIISSTIT GDVVLAAAYS HELPRYGITH GLTNWAAAYA 101 TGLLIARRTL QKLGLDETYK GVEEVEGEYE LTEAVEDGPR PFKVFLDIGL 151 QRTTTGARVF GALKGASDGG LYVPHSENRF PGWDFETEEI DPELLRSYIF 201 GGHVSQYMEE LADDDEERFS ELFKGYLADD IDADSLEDIY TSAHEAIRAD 251 PAFKPTEKKF TKEQYAAESK KYRQTKLSKE ERAARVAAKI AALAGQQ*

Amino Acid Sequence (or in FASTA format)

       1  MAFQKDAKSS AYSSRFQTPF RRRREGKTDY YQRKRLVTQH KAKYNTPKYR
      51  LVVRFTNKDI ICQIISSTIT GDVVLAAAYS HELPRYGITH GLTNWAAAYA
     101  TGLLIARRTL QKLGLDETYK GVEEVEGEYE LTEAVEDGPR PFKVFLDIGL
     151  QRTTTGARVF GALKGASDGG LYVPHSENRF PGWDFETEEI DPELLRSYIF
     201  GGHVSQYMEE LADDDEERFS ELFKGYLADD IDADSLEDIY TSAHEAIRAD
     251  PAFKPTEKKF TKEQYAAESK KYRQTKLSKE ERAARVAAKI AALAGQQ*

external links for Rpl5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Rpl5p

1)	Lopez N, et al. (1999) SSB, encoding a ribosome-associated chaperone, is coordinately regulated with ribosomal protein genes. J Bacteriol 181(10):3136-43
2)	Deshmukh M, et al. (1995) Multiple regions of yeast ribosomal protein L1 are important for its interaction with 5 S rRNA and assembly into ribosomes. J Biol Chem 270(50):30148-56
3)	Nazar RN, et al. (1979) The 5-S RNA binding protein from yeast (Saccharomyces cerevisiae) ribosomes. Evolution of the eukaryotic 5-S RNA binding protein. Eur J Biochem 102(2):573-82
4)	Planta RJ and Mager WH (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
5)	Lecompte O, et al. (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale. Nucleic Acids Res 30(24):5382-90
6)	Jenner L, et al. (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67