HHO1/YPL127C Protein Information

Standard Name	Hho1p 1
Systematic Name	Ypl127cp
ORF Classification	Verified
Description	Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination (1, 2, 3, 4, 5, 6, 7, 8, 9)
Name Description	Histone H One 1

Experimental Data
Molecules/cell	6560 10

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	258
Molecular Weight (Da)	27,803
Isoelectric Point (pI)	11.02

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hho1p (InterPro)
Physical Interactions	There are 42 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012BF45 \| P53551 MIPS: YPL127C NCBI: 1244786 \| 157880433 \| 159163141 \| 1708096 \| 45269403 \| 47169271 \| 6325130 \| 67463913 \| NP_015198.1 GenBank/EMBL/DDBJ: DAA11306.1 \| AY557756 \| U43703

Amino Acid Sequence (or in FASTA format)
1 MAPKKSTTKT TSKGKKPATS KGKEKSTSKA AIKKTTAKKE EASSKSYREL 51 IIEGLTALKE RKGSSRPALK KFIKENYPIV GSASNFDLYF NNAIKKGVEA 101 GDFEQPKGPA GAVKLAKKKS PEVKKEKEVS PKPKQAATSV SATASKAKAA 151 STKLAPKKVV KKKSPTVTAK KASSPSSLTY KEMILKSMPQ LNDGKGSSRI 201 VLKKYVKDTF SSKLKTSSNF DYLFNSAIKK CVENGELVQP KGPSGIIKLN 251 KKKVKLST*

Amino Acid Sequence (or in FASTA format)

       1  MAPKKSTTKT TSKGKKPATS KGKEKSTSKA AIKKTTAKKE EASSKSYREL
      51  IIEGLTALKE RKGSSRPALK KFIKENYPIV GSASNFDLYF NNAIKKGVEA
     101  GDFEQPKGPA GAVKLAKKKS PEVKKEKEVS PKPKQAATSV SATASKAKAA
     151  STKLAPKKVV KKKSPTVTAK KASSPSSLTY KEMILKSMPQ LNDGKGSSRI
     201  VLKKYVKDTF SSKLKTSSNF DYLFNSAIKK CVENGELVQP KGPSGIIKLN
     251  KKKVKLST*

external links for Hho1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Hho1p

1)	Ushinsky SC, et al. (1997) Histone H1 in Saccharomyces cerevisiae. Yeast 13(2):151-61
2)	Patterton HG, et al. (1998) The biochemical and phenotypic characterization of Hho1p, the putative linker histone H1 of Saccharomyces cerevisiae. J Biol Chem 273(13):7268-76
3)	Puig S, et al. (1999) Stochastic nucleosome positioning in a yeast chromatin region is not dependent on histone H1. Curr Microbiol 39(3):168-72
4)	Escher D and Schaffner W (1997) Gene activation at a distance and telomeric silencing are not affected by yeast histone H1. Mol Gen Genet 256(4):456-61
5)	Hellauer K, et al. (2001) Decreased expression of specific genes in yeast cells lacking histone H1. J Biol Chem 276(17):13587-92
6)	Landsman D (1996) Histone H1 in Saccharomyces cerevisiae: a double mystery solved? Trends Biochem Sci 21(8):287-8
7)	Freidkin I and Katcoff DJ (2001) Specific distribution of the Saccharomyces cerevisiae linker histone homolog HHO1p in the chromatin. Nucleic Acids Res 29(19):4043-51
8)	Downs JA, et al. (2003) Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Mol Cell 11(6):1685-92
9)	Bryant JM, et al. (2012) The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae. Mol Cell Biol 32(14):2771-83
10)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41