TFB2/YPL122C Protein Information

Standard Name	Tfb2p
Systematic Name	Ypl122cp
ORF Classification	Verified
Description	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH (1, 2, 3)
Name Description	Transcription initiation Factor IIB

Experimental Data
Molecules/cell	8900 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	513
Molecular Weight (Da)	58,534
Isoelectric Point (pI)	6.81

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tfb2p (InterPro)
Physical Interactions	There are 36 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006BEA4 \| Q02939 MIPS: YPL122C NCBI: 1163092 \| 1778059 \| 197107383 \| 197107449 \| 197107451 \| 62901134 \| 6325135 \| NP_015203.1 \| NM_001183936.1 GenBank/EMBL/DDBJ: DAA11311.1 \| U43503 \| U62804

Amino Acid Sequence (or in FASTA format)
1 MSDYSLKHSV TQYLEEIPQQ VQNRLYTSPA TCLAIYRILP PLAKFFIMAM 51 VFNENEVPLL DLDKWVNSNG KLQFQNAIKS MKSLHLLIPN KSSGTLMINL 101 NPTFKISLRN ALTGGEVQNS FGVVVEENVV SLDLLDEYSA NKWETILHFM 151 VGTPLAKIPS EKVLNLLKHS KLMEEVNSTG EFKITNEGFQ FLLQEINSQL 201 WTLLLQYLKM IETSKMDLVD VLHFIFMLGA LEVGKAYKID ALSETQRIML 251 QDMRDYGLVF QKHSNDSIFY PTKLALMLTS DTKTIRSASN AMDSVLRQNR 301 EEPSVNEDGA NGKSTTDITT SDDLNKAGLK NQDIPDGSLI VETNFKIYSY 351 SNSPLQIAVL SLFVHLKARF VNMVLGQITR ESIRRALTNG ITADQIIAYL 401 ETHAHPQMRR LAEEKLEKKL ELDPNCKEPL QVLPPTVVDQ IRLWQLELDR 451 VITYEGSLYS DFETSQEYNL LSKYAQDIGV LLWKDDKKKK FFISKEGNSQ 501 VLDFAKRKLK KKQ*

Amino Acid Sequence (or in FASTA format)

       1  MSDYSLKHSV TQYLEEIPQQ VQNRLYTSPA TCLAIYRILP PLAKFFIMAM
      51  VFNENEVPLL DLDKWVNSNG KLQFQNAIKS MKSLHLLIPN KSSGTLMINL
     101  NPTFKISLRN ALTGGEVQNS FGVVVEENVV SLDLLDEYSA NKWETILHFM
     151  VGTPLAKIPS EKVLNLLKHS KLMEEVNSTG EFKITNEGFQ FLLQEINSQL
     201  WTLLLQYLKM IETSKMDLVD VLHFIFMLGA LEVGKAYKID ALSETQRIML
     251  QDMRDYGLVF QKHSNDSIFY PTKLALMLTS DTKTIRSASN AMDSVLRQNR
     301  EEPSVNEDGA NGKSTTDITT SDDLNKAGLK NQDIPDGSLI VETNFKIYSY
     351  SNSPLQIAVL SLFVHLKARF VNMVLGQITR ESIRRALTNG ITADQIIAYL
     401  ETHAHPQMRR LAEEKLEKKL ELDPNCKEPL QVLPPTVVDQ IRLWQLELDR
     451  VITYEGSLYS DFETSQEYNL LSKYAQDIGV LLWKDDKKKK FFISKEGNSQ
     501  VLDFAKRKLK KKQ*

external links for Tfb2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Tfb2p

1)	Feaver WJ, et al. (1997) Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits. J Biol Chem 272(31):19319-27
2)	Prakash S and Prakash L (2000) Nucleotide excision repair in yeast. Mutat Res 451(1-2):13-24
3)	Lee TI and Young RA (2000) Transcription of eukaryotic protein-coding genes. Annu Rev Genet 34:77-137
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41