DBP1/YPL119C Protein Information Help

Standard Name Dbp1p
Systematic Name Ypl119cp
Alias Lph8p
ORF Classification Verified
Description Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress; DBP1 has a paralog, DED1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Dead Box Protein
Experimental Data
Molecules/cell 1480 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 617
Molecular Weight (Da) 67,917
Isoelectric Point (pI) 9.53

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Dbp1p (InterPro)
Physical Interactions There are 13 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000128F29 | P24784
MIPS: YPL119C
NCBI: 1163095 | 1706311 | 3641 | 6325138 | NP_015206.1 | NM_001183933.1
GenBank/EMBL/DDBJ: DAA11315.1 | U43503 | X55993
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
EC: 3.6.4.13 [RNA helicase]
Amino Acid Sequence (or in FASTA format)
 
       1  MADLPQKVSN LSINNKENGG GGGKSSYVPP HLRSRGKPSF ERSTPKQEDK
      51  VTGGDFFRRA GRQTGNNGGF FGFSKERNGG TSANYNRGGS SNYKSSGNRW
     101  VNGKHIPGPK NAKLEAELFG VHDDPDYHSS GIKFDNYDNI PVDASGKDVP
     151  EPILDFSSPP LDELLMENIK LASFTKPTPV QKYSIPIVTK GRDLMACAQT
     201  GSGKTGGFLF PLFTELFRSG PSPVPEKAQS FYSRKGYPSA LVLAPTRELA
     251  TQIFEEARKF TYRSWVRPCV VYGGAPIGNQ MREVDRGCDL LVATPGRLND
     301  LLERGKVSLA NIKYLVLDEA DRMLDMGFEP QIRHIVEECD MPSVENRQTL
     351  MFSATFPVDI QHLARDFLDN YIFLSVGRVG STSENITQRI LYVDDMDKKS
     401  ALLDLLSAEH KGLTLIFVET KRMADQLTDF LIMQNFKATA IHGDRTQAER
     451  ERALSAFKAN VADILVATAV AARGLDIPNV THVINYDLPS DIDDYVHRIG
     501  RTGRAGNTGV ATSFFNSNNQ NIVKGLMEIL NEANQEVPTF LSDLSRQNSR
     551  GGRTRGGGGF FNSRNNGSRD YRKHGGNGSF GSTRPRNTGT SNWGSIGGGF
     601  RNDNEKNGYG NSNASWW*

external links for Dbp1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Dbp1p
1) Jamieson DJ and Beggs JD  (1991) A suppressor of yeast spp81/ded1 mutations encodes a very similar putative ATP-dependent RNA helicase. Mol Microbiol 5(4):805-12
2) Berthelot K, et al.  (2004) Dynamics and processivity of 40S ribosome scanning on mRNA in yeast. Mol Microbiol 51(4):987-1001
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41