SSE1/YPL106C Protein Information Help

Standard Name Sse1p
Systematic Name Ypl106cp
Alias Lpg3p , Msi3p
ORF Classification Verified
Description ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication (1, 2, 3, 4)
Experimental Data
Molecules/cell 71700 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 693
Molecular Weight (Da) 77,366
Isoelectric Point (pI) 4.97

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sse1p (InterPro)
Physical Interactions There are 229 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052F0A | P32589
MIPS: YPL106C
NCBI: 1151221 | 159795398 | 159795399 | 1708310 | 189096176 | 190613718 | 190613720 | 190613722 | 190613724 | 218445 | 533365 | 550536 | 551301 | 6325151 | NP_015219.1
GenBank/EMBL/DDBJ: DAA11327.1 | D13319 | D13743 | D38368 | D38370 | U43281
Amino Acid Sequence (or in FASTA format)
 
       1  MSTPFGLDLG NNNSVLAVAR NRGIDIVVNE VSNRSTPSVV GFGPKNRYLG
      51  ETGKNKQTSN IKNTVANLKR IIGLDYHHPD FEQESKHFTS KLVELDDKKT
     101  GAEVRFAGEK HVFSATQLAA MFIDKVKDTV KQDTKANITD VCIAVPPWYT
     151  EEQRYNIADA ARIAGLNPVR IVNDVTAAGV SYGIFKTDLP EGEEKPRIVA
     201  FVDIGHSSYT CSIMAFKKGQ LKVLGTACDK HFGGRDFDLA ITEHFADEFK
     251  TKYKIDIREN PKAYNRILTA AEKLKKVLSA NTNAPFSVES VMNDVDVSSQ
     301  LSREELEELV KPLLERVTEP VTKALAQAKL SAEEVDFVEI IGGTTRIPTL
     351  KQSISEAFGK PLSTTLNQDE AIAKGAAFIC AIHSPTLRVR PFKFEDIHPY
     401  SVSYSWDKQV EDEDHMEVFP AGSSFPSTKL ITLNRTGDFS MAASYTDITQ
     451  LPPNTPEQIA NWEITGVQLP EGQDSVPVKL KLRCDPSGLH TIEEAYTIED
     501  IEVEEPIPLP EDAPEDAEQE FKKVTKTVKK DDLTIVAHTF GLDAKKLNEL
     551  IEKENEMLAQ DKLVAETEDR KNTLEEYIYT LRGKLEEEYA PFASDAEKTK
     601  LQGMLNKAEE WLYDEGFDSI KAKYIAKYEE LASLGNIIRG RYLAKEEEKK
     651  QAIRSKQEAS QMAAMAEKLA AQRKAEAEKK EEKKDTEGDV DMD*

external links for Sse1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Sse1p
1) Liu XD, et al.  (1999) The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone. J Biol Chem 274(38):26654-60
2) Goeckeler JL, et al.  (2002) Overexpression of yeast Hsp110 homolog Sse1p suppresses ydj1-151 thermosensitivity and restores Hsp90-dependent activity. Mol Biol Cell 13(8):2760-70
3) Shaner L, et al.  (2004) The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family. J Biol Chem 279(21):21992-2001
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41