ATG21/YPL100W Protein Information

Standard Name	Atg21p 1
Systematic Name	Ypl100wp
Alias	Mai1p 2 , Hsv1p 3
ORF Classification	Verified
Description	Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein (2, 3)
Name Description	AuTophaGy related 1

Experimental Data
Molecules/cell	6020 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	496
Molecular Weight (Da)	55,188
Isoelectric Point (pI)	7.45

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Atg21p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B0AE \| Q02887 MIPS: YPL100W NCBI: 1151226 \| 61211711 \| 6325157 \| NP_015225.1 GenBank/EMBL/DDBJ: DAA11332.1 \| U43281

Amino Acid Sequence (or in FASTA format)
1 MKVLQFNQDA TCCVVAASSH QISIFNCDPF GKCFEIDTKN SKKKTSNNNG 51 SASNSESRNN EESILITNGS RDRTDAEEEE DNEDNALVTG NILKEGEFVI 101 EMLFSTSLIA IADRGQGLNK GKKLKIVNTK RKCTICEIVF PHEIVDVVMN 151 RKRMCVLLES DQIFIYDISC MKPLETIDLW EDHYKRSQAN SFSNASNTGT 201 LEGDSANLNR VATNLLANAT QKSVNGSNPS VRTRRNSLRS KIRPRMVLSN 251 DDRSILCFTA YSSPKKNKPN SEALYDVVIY DTLNVTPVNY LNSVHKGNVA 301 CLAVSHDGKL LATASDKGTI IRVFHTGVDS DYMSSRSLFK EFRRGTRLCN 351 LYQLAFDKSM TMIGCVGDTD TIHLFKLDDA SNSLPGDNSS NGHWNEEEYI 401 LASNSNPSMG TPKEIPLSKP RIANYFSKKI KSSIPNQNLS RNFAYITVNE 451 SNRSCLGFPD EFPNQVYIAS DDGTFSIYSI PSKPGECVLT KNNKFT*

Amino Acid Sequence (or in FASTA format)

       1  MKVLQFNQDA TCCVVAASSH QISIFNCDPF GKCFEIDTKN SKKKTSNNNG
      51  SASNSESRNN EESILITNGS RDRTDAEEEE DNEDNALVTG NILKEGEFVI
     101  EMLFSTSLIA IADRGQGLNK GKKLKIVNTK RKCTICEIVF PHEIVDVVMN
     151  RKRMCVLLES DQIFIYDISC MKPLETIDLW EDHYKRSQAN SFSNASNTGT
     201  LEGDSANLNR VATNLLANAT QKSVNGSNPS VRTRRNSLRS KIRPRMVLSN
     251  DDRSILCFTA YSSPKKNKPN SEALYDVVIY DTLNVTPVNY LNSVHKGNVA
     301  CLAVSHDGKL LATASDKGTI IRVFHTGVDS DYMSSRSLFK EFRRGTRLCN
     351  LYQLAFDKSM TMIGCVGDTD TIHLFKLDDA SNSLPGDNSS NGHWNEEEYI
     401  LASNSNPSMG TPKEIPLSKP RIANYFSKKI KSSIPNQNLS RNFAYITVNE
     451  SNRSCLGFPD EFPNQVYIAS DDGTFSIYSI PSKPGECVLT KNNKFT*

external links for Atg21p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Atg21p

1)	Klionsky DJ, et al. (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5(4):539-45
2)	Barth H, et al. (2002) Mai1p is essential for maturation of proaminopeptidase I but not for autophagy. FEBS Lett 512(1-3):173-9
3)	Dove SK, et al. (2004) Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J 23(9):1922-33
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41