NOG1/YPL093W Protein Information

Standard Name	Nog1p
Systematic Name	Ypl093wp
ORF Classification	Verified
Description	Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins (1, 2, 3)
Name Description	NucleOlar G-protein 1

Experimental Data
Molecules/cell	28000 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	647
Molecular Weight (Da)	74,409
Isoelectric Point (pI)	9.38

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Nog1p (InterPro)
Physical Interactions	There are 288 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052E39 \| Q02892 MIPS: YPL093W NCBI: 1151233 \| 17368412 \| 6325164 \| NP_015232.1 GenBank/EMBL/DDBJ: DAA11340.1 \| U43281

Amino Acid Sequence (or in FASTA format)
1 MQLSWKDIPT VAPANDLLDI VLNRTQRKTP TVIRPGFKIT RIRAFYMRKV 51 KYTGEGFVEK FEDILKGFPN INDVHPFHRD LMDTLYEKNH YKISLAAISR 101 AKSLVEQVAR DYVRLLKFGQ SLFQCKQLKR AALGRMATIV KKLRDPLAYL 151 EQVRQHIGRL PSIDPNTRTL LICGYPNVGK SSFLRCITKS DVDVQPYAFT 201 TKSLYVGHFD YKYLRFQAID TPGILDRPTE EMNNIEMQSI YAIAHLRSCV 251 LYFMDLSEQC GFTIEAQVKL FHSIKPLFAN KSVMVVINKT DIIRPEDLDE 301 ERAQLLESVK EVPGVEIMTS SCQLEENVME VRNKACEKLL ASRIENKLKS 351 QSRINNVLNK IHVAQPQARD DVKRTPFIPE SVKNLKKYDP EDPNRRKLAR 401 DIEAENGGAG VFNVNLKDKY LLEDDEWKND IMPEILDGKN VYDFLDPEIA 451 AKLQALEEEE EKLENEGFYN SDDEEEIYDG FEASEVDDIK EKAAWIRNRQ 501 KTMIAEARNR KSLKNKAIMP RSKLTKSFGK MEEHMSTLGH DMSALQDKQN 551 RAARKNRYVE RGSDVVFGDQ DALTASTENG VKLRQTDRLL DGVADGSMRS 601 KADRMAKMER RERNRHAKQG ESDRHNAVSL SKHLFSGKRG VGKTDFR*

Amino Acid Sequence (or in FASTA format)

       1  MQLSWKDIPT VAPANDLLDI VLNRTQRKTP TVIRPGFKIT RIRAFYMRKV
      51  KYTGEGFVEK FEDILKGFPN INDVHPFHRD LMDTLYEKNH YKISLAAISR
     101  AKSLVEQVAR DYVRLLKFGQ SLFQCKQLKR AALGRMATIV KKLRDPLAYL
     151  EQVRQHIGRL PSIDPNTRTL LICGYPNVGK SSFLRCITKS DVDVQPYAFT
     201  TKSLYVGHFD YKYLRFQAID TPGILDRPTE EMNNIEMQSI YAIAHLRSCV
     251  LYFMDLSEQC GFTIEAQVKL FHSIKPLFAN KSVMVVINKT DIIRPEDLDE
     301  ERAQLLESVK EVPGVEIMTS SCQLEENVME VRNKACEKLL ASRIENKLKS
     351  QSRINNVLNK IHVAQPQARD DVKRTPFIPE SVKNLKKYDP EDPNRRKLAR
     401  DIEAENGGAG VFNVNLKDKY LLEDDEWKND IMPEILDGKN VYDFLDPEIA
     451  AKLQALEEEE EKLENEGFYN SDDEEEIYDG FEASEVDDIK EKAAWIRNRQ
     501  KTMIAEARNR KSLKNKAIMP RSKLTKSFGK MEEHMSTLGH DMSALQDKQN
     551  RAARKNRYVE RGSDVVFGDQ DALTASTENG VKLRQTDRLL DGVADGSMRS
     601  KADRMAKMER RERNRHAKQG ESDRHNAVSL SKHLFSGKRG VGKTDFR*

external links for Nog1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Nog1p

1)	Park JH, et al. (2001) A novel nucleolar G-protein conserved in eukaryotes. J Cell Sci 114(Pt 1):173-185
2)	Kallstrom G, et al. (2003) The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Mol Cell Biol 23(12):4344-55
3)	Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41