RGL1/YPL066W Protein Information

Standard Name	Rgl1p 1
Systematic Name	Ypl066wp
ORF Classification	Verified
Description	Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source (1, 2, 3)
Name Description	Rho1 GEF Localizing 1

Experimental Data
Molecules/cell	396 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	479
Molecular Weight (Da)	54,893
Isoelectric Point (pI)	10.19

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rgl1p (InterPro)
Physical Interactions	There are 12 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053274 \| Q12194 MIPS: YPL066W NCBI: 1079676 \| 2499126 \| 6325191 \| NP_015259.1 GenBank/EMBL/DDBJ: DAA11365.1 \| U39205 \| U50630

Amino Acid Sequence (or in FASTA format)
1 MTHPVISLKP SYNSVIRGCP GLPDTLPRIE CQLRVRSNNS LPFKLVKIEI 51 VLKTIEIYFN KNLYSSNNSS FTPFNRPSDP SNGHSDTSNQ NISIHYKKNI 101 VLSHPTHDGD DLNNDLIGID IPLTIGLPDD IKETNYNPKF GKTQTFLDCT 151 VFYTEVGGGS SNKKRNFLYP VNVERYTYLP SPSYFRPINR SNITSPDQKF 201 LISYSIENPC VSMNNDTLKL SISIRLNPFP NNATTPSSND FDVSTPTLFS 251 TKKKFKSKLK LKSITTQILE YLEILKNQSE FSSTQTTNIL QTSVRQVDQI 301 ISMNSMIFQF NLKIFTKDKI LQSFRSSESS CPETKVLINK IDDIPLQYHS 351 SITTIGQHFN VSHYLSIRFK FNKSLKNFEI NHPLIISFWS VSQLPLIENL 401 ILQERQTAKF AKKFYKNFGR IKNTSNNNNS SNCLEYPSLP PIIYNFNDPE 451 TNNRFNILYS QKDPSRTDPS KLRRVPVIQ*

Amino Acid Sequence (or in FASTA format)

       1  MTHPVISLKP SYNSVIRGCP GLPDTLPRIE CQLRVRSNNS LPFKLVKIEI
      51  VLKTIEIYFN KNLYSSNNSS FTPFNRPSDP SNGHSDTSNQ NISIHYKKNI
     101  VLSHPTHDGD DLNNDLIGID IPLTIGLPDD IKETNYNPKF GKTQTFLDCT
     151  VFYTEVGGGS SNKKRNFLYP VNVERYTYLP SPSYFRPINR SNITSPDQKF
     201  LISYSIENPC VSMNNDTLKL SISIRLNPFP NNATTPSSND FDVSTPTLFS
     251  TKKKFKSKLK LKSITTQILE YLEILKNQSE FSSTQTTNIL QTSVRQVDQI
     301  ISMNSMIFQF NLKIFTKDKI LQSFRSSESS CPETKVLINK IDDIPLQYHS
     351  SITTIGQHFN VSHYLSIRFK FNKSLKNFEI NHPLIISFWS VSQLPLIENL
     401  ILQERQTAKF AKKFYKNFGR IKNTSNNNNS SNCLEYPSLP PIIYNFNDPE
     451  TNNRFNILYS QKDPSRTDPS KLRRVPVIQ*

external links for Rgl1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rgl1p

1)	Krause SA, et al. (2012) Functional specialisation of yeast Rho1 GTP exchange factors. J Cell Sci 125(Pt 11):2721-31
2)	Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41