ALD6/YPL061W Protein Information

Standard Name	Ald6p
Systematic Name	Ypl061wp
Alias	Ald1p 1
ORF Classification	Verified
Description	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress (2, 3, 4)
Name Description	ALdehyde Dehydrogenase

Experimental Data
Molecules/cell	135000 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	500
Molecular Weight (Da)	54,414
Isoelectric Point (pI)	5.18

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ald6p (InterPro)
Physical Interactions	There are 31 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000016842E \| P54115 \| A9LRZ7 MIPS: YPL061W NCBI: 1336076 \| 20981689 \| 6325196 \| NP_015264.1 GenBank/EMBL/DDBJ: DAA11369.1 \| U39205 \| U56604
External Classifications	EC: 1.2.1.4 [Aldehyde dehydrogenase (NADP(+))]

Amino Acid Sequence (or in FASTA format)
1 MTKLHFDTAE PVKITLPNGL TYEQPTGLFI NNKFMKAQDG KTYPVEDPST 51 ENTVCEVSSA TTEDVEYAIE CADRAFHDTE WATQDPRERG RLLSKLADEL 101 ESQIDLVSSI EALDNGKTLA LARGDVTIAI NCLRDAAAYA DKVNGRTINT 151 GDGYMNFTTL EPIGVCGQII PWNFPIMMLA WKIAPALAMG NVCILKPAAV 201 TPLNALYFAS LCKKVGIPAG VVNIVPGPGR TVGAALTNDP RIRKLAFTGS 251 TEVGKSVAVD SSESNLKKIT LELGGKSAHL VFDDANIKKT LPNLVNGIFK 301 NAGQICSSGS RIYVQEGIYD ELLAAFKAYL ETEIKVGNPF DKANFQGAIT 351 NRQQFDTIMN YIDIGKKEGA KILTGGEKVG DKGYFIRPTV FYDVNEDMRI 401 VKEEIFGPVV TVAKFKTLEE GVEMANSSEF GLGSGIETES LSTGLKVAKM 451 LKAGTVWINT YNDFDSRVPF GGVKQSGYGR EMGEEVYHAY TEVKAVRIKL 501 *

Amino Acid Sequence (or in FASTA format)

       1  MTKLHFDTAE PVKITLPNGL TYEQPTGLFI NNKFMKAQDG KTYPVEDPST
      51  ENTVCEVSSA TTEDVEYAIE CADRAFHDTE WATQDPRERG RLLSKLADEL
     101  ESQIDLVSSI EALDNGKTLA LARGDVTIAI NCLRDAAAYA DKVNGRTINT
     151  GDGYMNFTTL EPIGVCGQII PWNFPIMMLA WKIAPALAMG NVCILKPAAV
     201  TPLNALYFAS LCKKVGIPAG VVNIVPGPGR TVGAALTNDP RIRKLAFTGS
     251  TEVGKSVAVD SSESNLKKIT LELGGKSAHL VFDDANIKKT LPNLVNGIFK
     301  NAGQICSSGS RIYVQEGIYD ELLAAFKAYL ETEIKVGNPF DKANFQGAIT
     351  NRQQFDTIMN YIDIGKKEGA KILTGGEKVG DKGYFIRPTV FYDVNEDMRI
     401  VKEEIFGPVV TVAKFKTLEE GVEMANSSEF GLGSGIETES LSTGLKVAKM
     451  LKAGTVWINT YNDFDSRVPF GGVKQSGYGR EMGEEVYHAY TEVKAVRIKL
     501  *

external links for Ald6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ald6p

1)	Wang X, et al. (1998) Molecular cloning, characterization, and potential roles of cytosolic and mitochondrial aldehyde dehydrogenases in ethanol metabolism in Saccharomyces cerevisiae. J Bacteriol 180(4):822-30
2)	Navarro-Avino JP, et al. (1999) A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes. Yeast 15(10A):829-42
3)	Saint-Prix F, et al. (2004) Functional analysis of the ALD gene family of Saccharomyces cerevisiae during anaerobic growth on glucose: the NADP+-dependent Ald6p and Ald5p isoforms play a major role in acetate formation. Microbiology 150(Pt 7):2209-20
4)	Rinnerthaler M, et al. (2006) MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria. Biochim Biophys Acta 1757(5-6):631-8
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41