KTR6/YPL053C Protein Information

Standard Name	Ktr6p
Systematic Name	Ypl053cp
Alias	Mnn6p
ORF Classification	Verified
Description	Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication (1, 2)
Name Description	Kre Two Related 1

Experimental Data
Molecules/cell	4380 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	446
Molecular Weight (Da)	52,128
Isoelectric Point (pI)	5.25

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ktr6p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 7 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012E11F \| P54070 MIPS: YPL053C NCBI: 1079689 \| 1730074 \| 2264390 \| 6325204 \| NP_015272.1 GenBank/EMBL/DDBJ: DAA11377.1 \| U39205 \| U43922
External Classifications	EC: 2.4.1.- [Hexosyltransferases] EC: 2.4.1.131 [GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MHVLLSKKIA RFLLISFVFV LALMVTINHP KTKQMSEQYV TPYLPKSLQP 51 IAKISAEEQR RIQSEQEEAE LKQSLEGEAI RNATVNAIKE KIKSYGGNET 101 TLGFMVPSYI NHRGSPPKAC FVSLITERDS MTQILQSIDE VQVKFNKNFA 151 YPWVFISQGE LDGMKQEMIR QAITDSMNGD PELINIKFAE IPADEWVYPE 201 WIDENKAAES LISLANVPDG DSRAVRYQAR YFAGFFWRHP VLDEFDWYWR 251 VDPGIKLYCD IDHDLFRWMQ DEGKVFGFTL SMSEAKEANE KIWDVTKKFA 301 KDFPKFISEN NFKSFITKKD SEDFNNCEFT SNFEIGNLNF YRSPAYRKFF 351 NYIDEEGGIF YWKWSDSIIH TIGLSMLLPK DKIHFFENIG FHYDKYNNCP 401 LNDDIWNQYN CNCDQGNDFT FRSGSCGGHY FDIMKKDKPE GWDRLP*

Amino Acid Sequence (or in FASTA format)

       1  MHVLLSKKIA RFLLISFVFV LALMVTINHP KTKQMSEQYV TPYLPKSLQP
      51  IAKISAEEQR RIQSEQEEAE LKQSLEGEAI RNATVNAIKE KIKSYGGNET
     101  TLGFMVPSYI NHRGSPPKAC FVSLITERDS MTQILQSIDE VQVKFNKNFA
     151  YPWVFISQGE LDGMKQEMIR QAITDSMNGD PELINIKFAE IPADEWVYPE
     201  WIDENKAAES LISLANVPDG DSRAVRYQAR YFAGFFWRHP VLDEFDWYWR
     251  VDPGIKLYCD IDHDLFRWMQ DEGKVFGFTL SMSEAKEANE KIWDVTKKFA
     301  KDFPKFISEN NFKSFITKKD SEDFNNCEFT SNFEIGNLNF YRSPAYRKFF
     351  NYIDEEGGIF YWKWSDSIIH TIGLSMLLPK DKIHFFENIG FHYDKYNNCP
     401  LNDDIWNQYN CNCDQGNDFT FRSGSCGGHY FDIMKKDKPE GWDRLP*

external links for Ktr6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Ktr6p

1)	Lussier M, et al. (1997) Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Yeast 13(3):267-74
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41