ARL3/YPL051W Protein Information Help

Standard Name Arl3p 1
Systematic Name Ypl051wp
ORF Classification Verified
Description ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1 (1, 2, 3)
Name Description ADP-Ribosylation factor-Like 1
Experimental Data
Molecules/cell 1920 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 198
Molecular Weight (Da) 22,782
Isoelectric Point (pI) 6.31

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Arl3p (InterPro)
Physical Interactions There are 13 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000069737 | Q02804
MIPS: YPL051W
NCBI: 1079691 | 2736079 | 45270536 | 51315831 | 6325206 | NP_015274.1 | NM_001183865.1
GenBank/EMBL/DDBJ: AAB68314.1 | AAD13357.1 | AAS56649.1 | DAA11379.1 | AF017142 | AY558323 | U39205
Amino Acid Sequence (or in FASTA format)
       1  MFHLVKGLYN NWNKKEQYSI LILGLDNAGK TTFLETLKKE YSLAFKALEK
      51  IQPTVGQNVA TIPVDSKQIL KFWDVGGQES LRSMWSEYYS LCHGIIFIVD
     101  SSDRERLDEC STTLQSVVMD EEIEGVPILM LANKQDRQDR MEVQDIKEVF
     151  NKIAEHISAR DSRVLPISAL TGEGVKDAIE WMIVRLERNK KSRPPIYK* 

external links for Arl3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Arl3p
1) Huang CF, et al.  (1999) Characterization of a novel ADP-ribosylation factor-like protein (yARL3) in Saccharomyces cerevisiae. J Biol Chem 274(6):3819-27
2) Behnia R, et al.  (2004) Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. Nat Cell Biol 6(5):405-13
3) Setty SR, et al.  (2004) Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Nat Cell Biol 6(5):414-9
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41