SSN3/YPL042C Protein Information Help

Standard Name Ssn3p 1
Systematic Name Ypl042cp
Alias Gig2p 2 , Nut7p 3 , Srb10p 4 , Ume5p 5 , Rye5p , Cdk8p 6 , Ssx7p 7 , Urr1p 8
ORF Classification Verified
Description Cyclin-dependent protein kinase; component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression (2, 4, 9)
Name Description Suppressor of SNf1 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 555
Molecular Weight (Da) 62,847
Isoelectric Point (pI) 10.4

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ssn3p (InterPro)
Physical Interactions There are 124 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053162 | P39073
MIPS: YPL042C
NCBI: 114152902 | 1171416 | 1351369 | 439215 | 6325215 | 662800 | NP_015283.1 | NM_001183856.1
GenBank/EMBL/DDBJ: AAA35193.1 | AAB68178.1 | AAC13785.1 | DAA11387.1 | L27151 | U20222 | U44030
External Classifications EC: 2.7.11.22 [Cyclin-dependent kinase]
EC: 2.7.11.23 [[RNA-polymerase]-subunit kinase]
Amino Acid Sequence (or in FASTA format)
       1  MYNGKDRAQN SYQPMYQRPM QVQGQQQAQS FVGKKNTIGS VHGKAPMLMA
      51  NNDVFTIGPY RARKDRMRVS VLEKYEVIGY IAAGTYGKVY KAKRQINSGT
     101  NSANGSSLNG TNAKIPQFDS TQPKSSSSMD MQANTNALRR NLLKDEGVTP
     151  GRIRTTREDV SPHYNSQKQT LIKKPLTVFY AIKKFKTEKD GVEQLHYTGI
     201  SQSACREMAL CRELHNKHLT TLVEIFLERK CVHMVYEYAE HDLLQIIHFH
     251  SHPEKRMIPP RMVRSIMWQL LDGVSYLHQN WVLHRDLKPA NIMVTIDGCV
     301  KIGDLGLARK FHNMLQTLYT GDKVVVTIWY RAPELLLGAR HYTPAVDLWS
     351  VGCIFAELIG LQPIFKGEEA KLDSKKTVPF QVNQLQRILE VLGTPDQKIW
     401  PYLEKYPEYD QITKFPKYRD NLATWYHSAG GRDKHALSLL YHLLNYDPIK
     451  RIDAFNALEH KYFTESDIPV SENVFEGLTY KYPARRIHTN DNDIMNLGSR
     501  TKNNTQASGI TAGAAANALG GLGVNRRILA AAAAAAAAVS GNNASDEPSR
     551  KKNRR*                                                

external links for Ssn3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) CYC2008 (complexes) MIPS
Candida (CGD) Complexome Pfam domains
YGOB DIP

YOGY GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Ssn3p
1) Carlson M, et al.  (1984) A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast. Genetics 107(1):19-32
2) Balciunas D and Ronne H  (1995) Three subunits of the RNA polymerase II mediator complex are involved in glucose repression. Nucleic Acids Res 23(21):4421-5
3) Tabtiang RK and Herskowitz I  (1998) Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae. Mol Cell Biol 18(8):4707-18
4) Liao SM, et al.  (1995) A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374(6518):193-6
5) Surosky RT, et al.  (1994) The yeast UME5 gene regulates the stability of meiotic mRNAs in response to glucose. Mol Cell Biol 14(5):3446-58
6) Bourbon HM, et al.  (2004) A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 14(5):553-7
7) Li L, et al.  (2005) Genetic interactions between mediator and the late G1-specific transcription factor Swi6 in Saccharomyces cerevisiae. Genetics 171(2):477-88
8) Becker P and Johnston M  (2014) personal communication
9) Kuchin S, et al.  (1995) Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast. Proc Natl Acad Sci U S A 92(9):4006-10