SKS1/YPL026C Protein Information

Standard Name	Sks1p 1
Systematic Name	Ypl026cp
Alias	Sha3p
ORF Classification	Verified
Description	Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Suppressor Kinase of SNF3 1

Experimental Data
Molecules/cell	2810 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	502
Molecular Weight (Da)	57,843
Isoelectric Point (pI)	4.91

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sks1p (InterPro)
Physical Interactions	There are 64 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001359E7 \| Q12505 MIPS: YPL026C NCBI: 1039451 \| 1173541 \| 2499625 \| 6325231 \| NP_015299.1 GenBank/EMBL/DDBJ: DAA11403.1 \| U30613 \| U36624
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MLSDCLLNNF RITAQIGSGA YGLVFHVVDI LTSREYAVKT VFKSSSMDEF 51 YNKNGLNNNS QVARTTLLQT QLYHFFKSFQ KKLFLPSVDL DSILQLTENE 101 LNRLPHYREI AFQLRVQSHG NIVKIHQVLE SSIATFIVMD YYDRDLFTSI 151 VDDKHFVNHG ILIKKVFLQL CSALDHCHRL GIYHCDIKPE NVLLDRNDNA 201 YLCDFGLSTK SKYLAPNVCV GSSYYMAPER ILYCLNTTTN GIHVDECCSS 251 LPTDTGDIWS LGIILINLTC IRNPWLKAHQ KEDNTFQHFA NDNNVLKKIL 301 PISDELFTVL TKILQLNPYT RIDMKTLMSE VSSLTSFTRE GPLSQVPILS 351 SEVYMTHIIR NENLFLSDLS HFSADQEQQQ QQQQQQQQVQ EQEQEQKQEQ 401 IQNQEQAQQQ QEEEDAEPES DIPSTYNSDG SMEKYEYTNN HNNSTFLTSS 451 MDSTPYQSDI DDVSASKDCK FQQDTLRNRL LCLQMNFSTL TDGPNEKWLP 501 DY*

Amino Acid Sequence (or in FASTA format)

       1  MLSDCLLNNF RITAQIGSGA YGLVFHVVDI LTSREYAVKT VFKSSSMDEF
      51  YNKNGLNNNS QVARTTLLQT QLYHFFKSFQ KKLFLPSVDL DSILQLTENE
     101  LNRLPHYREI AFQLRVQSHG NIVKIHQVLE SSIATFIVMD YYDRDLFTSI
     151  VDDKHFVNHG ILIKKVFLQL CSALDHCHRL GIYHCDIKPE NVLLDRNDNA
     201  YLCDFGLSTK SKYLAPNVCV GSSYYMAPER ILYCLNTTTN GIHVDECCSS
     251  LPTDTGDIWS LGIILINLTC IRNPWLKAHQ KEDNTFQHFA NDNNVLKKIL
     301  PISDELFTVL TKILQLNPYT RIDMKTLMSE VSSLTSFTRE GPLSQVPILS
     351  SEVYMTHIIR NENLFLSDLS HFSADQEQQQ QQQQQQQQVQ EQEQEQKQEQ
     401  IQNQEQAQQQ QEEEDAEPES DIPSTYNSDG SMEKYEYTNN HNNSTFLTSS
     451  MDSTPYQSDI DDVSASKDCK FQQDTLRNRL LCLQMNFSTL TDGPNEKWLP
     501  DY*

external links for Sks1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Sks1p

1)	Yang Z and Bisson LF (1996) The SKS1 protein kinase is a multicopy suppressor of the snf3 mutation of Saccharomyces cerevisiae. Yeast 12(14):1407-19
2)	Vagnoli P and Bisson LF (1998) The SKS1 gene of Saccharomyces cerevisiae is required for long-term adaptation of snf3 null strains to low glucose. Yeast 14(4):359-69
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41