VTC3/YPL019C Protein Information Help

Standard Name Vtc3p 1
Systematic Name Ypl019cp
Alias Phm2p 2
ORF Classification Verified
Description Subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC3 has a paralog, VTC2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Vacuolar Transporter Chaperone 1
Experimental Data
Molecules/cell 2630 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 835
Molecular Weight (Da) 96,553
Isoelectric Point (pI) 7.48

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vtc3p (InterPro)
Transmembrane Domains There are 3 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 21 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006BCA2 | Q02725
MIPS: YPL019C
NCBI: 1039458 | 6325238 | 73622081 | NP_015306.1
GenBank/EMBL/DDBJ: DAA11409.1 | U36624
Amino Acid Sequence (or in FASTA format)
 
       1  MLFGIKLAND VYPPWKDSYI DYERLKKLLK ESVIHDGRSS VDSWSERNES
      51  DFVEALDKEL EKVYTFQISK YNAVLRKLDD LEENTKSAEK IQKINSEQFK
     101  NTLEECLDEA QRLDNFDRLN FTGFIKIVKK HDKLHPNYPS VKSLLQVRLK
     151  ELPFNNSEEY SPLLYRISYL YEFLRSNYDH PNTVSKSLAS TSKLSHFSNL
     201  EDASFKSYKF WVHDDNIMEV KARILRHLPA LVYASVPNEN DDFVDNLESD
     251  VRVQPEARLN IGSKSNSLSS DGNSNQDVEI GKSKSVIFPQ SYDPTITTLY
     301  FDNDFFDLYN NRLLKISGAP TLRLRWIGKL LDKPDIFLEK RTFTENTETG
     351  NSSFEEIRLQ MKAKFINNFI FKNDPSYKNY LINQLRERGT QKEELEKLSR
     401  DFDNIQNFIV EEKLQPVLRA TYNRTAFQIP GDQSIRVTID SNIMYIREDS
     451  LDKNRPIRNP ENWHRDDIDS NIPNPLRFLR AGEYSKFPYS VMEIKVINQD
     501  NSQMPNYEWI KDLTNSHLVN EVPKFSLYLQ GVASLFGEDD KYVNILPFWL
     551  PDLETDIRKN PQEAYEEEKK TLQKQKSIHD KLDNMRRLSK ISVPDGKTTE
     601  RQGQKDQNTR HVIADLEDHE SSDEEGTALP KKSAVKKGKK FKTNAAFLKI
     651  LAGKNISENG NDPYSDDTDS ASSFQLPPGV KKPVHLLKNA GPVKVEAKVW
     701  LANERTFNRW LSVTTLLSVL TFSIYNSVQK AEFPQLADLL AYVYFFLTLF
     751  CGVWAYRTYL KRLTLIKGRS GKHLDAPVGP ILVAVVLIVT LVVNFSVAFK
     801  EAARRERGLV NVSSQPSLPR TLKPIQDFIF NLVGE*

external links for Vtc3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Vtc3p
1) Cohen A, et al.  (1999) A novel family of yeast chaperons involved in the distribution of V-ATPase and other membrane proteins. J Biol Chem 274(38):26885-93
2) Ogawa N, et al.  (2000) New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis. Mol Biol Cell 11(12):4309-21
3) Muller O, et al.  (2002) The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation. EMBO J 21(3):259-69
4) Muller O, et al.  (2003) Role of the Vtc proteins in V-ATPase stability and membrane trafficking. J Cell Sci 116(Pt 6):1107-15
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41