CTF19/YPL018W Protein Information

Standard Name	Ctf19p 1
Systematic Name	Ypl018wp
Alias	Mcm18p
ORF Classification	Verified
Description	Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 (1, 2, 3, 4)
Name Description	Chromosome Transmission Fidelity 5

Experimental Data
Molecules/cell	1250 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	369
Molecular Weight (Da)	42,782
Isoelectric Point (pI)	8.73

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ctf19p (InterPro)
Physical Interactions	There are 160 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053269 \| Q02732 MIPS: YPL018W NCBI: 1039459 \| 1621635 \| 2498264 \| 6325239 \| NP_015307.1 GenBank/EMBL/DDBJ: DAA11410.1 \| U36624 \| U72265

Amino Acid Sequence (or in FASTA format)
1 MDFTSDTTNS HDTSNSHLSL EDAVGTHHAG EADVNIDGDE KQQLSLLDDD 51 QVRALKLQEE KDALLTRRNT LLQEIQTYQN ILMKENNSKT KNGDILQNDI 101 TQDFLNLISI SSSNPNSAIS DRKRVERING LTNLQKELVT KYDTLPLLNM 151 NLRLSYLRDH TYPHLQVSVQ SRDRVHNDGI EVLVVNYKFC RNTMNPFEIQ 201 FKMFYKFEDS TLLKWEILRI STNVRLKAKQ LLATRNFQKC LLSLYEFDKI 251 KSKKTGIFQN LINLLKRKTR CYLMNNSDSL IVERVIREGR LTTIKLQINF 301 IITMPGERGK PRNCFLPMSK ISIALWKGGE RFNQIDLDEI CYGLIKEYGV 351 KTGLKEICNV CLFPDMYAR*

Amino Acid Sequence (or in FASTA format)

       1  MDFTSDTTNS HDTSNSHLSL EDAVGTHHAG EADVNIDGDE KQQLSLLDDD
      51  QVRALKLQEE KDALLTRRNT LLQEIQTYQN ILMKENNSKT KNGDILQNDI
     101  TQDFLNLISI SSSNPNSAIS DRKRVERING LTNLQKELVT KYDTLPLLNM
     151  NLRLSYLRDH TYPHLQVSVQ SRDRVHNDGI EVLVVNYKFC RNTMNPFEIQ
     201  FKMFYKFEDS TLLKWEILRI STNVRLKAKQ LLATRNFQKC LLSLYEFDKI
     251  KSKKTGIFQN LINLLKRKTR CYLMNNSDSL IVERVIREGR LTTIKLQINF
     301  IITMPGERGK PRNCFLPMSK ISIALWKGGE RFNQIDLDEI CYGLIKEYGV
     351  KTGLKEICNV CLFPDMYAR*

external links for Ctf19p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Ctf19p

1)	Hyland KM, et al. (1999) Ctf19p: A novel kinetochore protein in Saccharomyces cerevisiae and a potential link between the kinetochore and mitotic spindle. J Cell Biol 145(1):15-28
2)	Ortiz J, et al. (1999) A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore. Genes Dev 13(9):1140-55
3)	De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21
4)	Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13
5)	Spencer F, et al. (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41