IRC15/YPL017C Protein Information

Standard Name	Irc15p 1
Systematic Name	Ypl017cp
ORF Classification	Verified
Description	Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci; IRC15 has a paralog, LPD1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Increased Recombination Centers 1

Experimental Data
Molecules/cell	6400 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	499
Molecular Weight (Da)	54,156
Isoelectric Point (pI)	5.87

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Irc15p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B516 \| Q02733 MIPS: YPL017C NCBI: 1039460 \| 6325240 \| 74676302 \| NP_015308.1 GenBank/EMBL/DDBJ: DAA11411.1 \| U36624

Amino Acid Sequence (or in FASTA format)
1 MGGEDEILST MEDFAAVYDV LVIGCGPGGF TAAMQASQAG LLTACVDQRA 51 SLGGAYLVDG AVPSKTLLYE SYLYRLLQQQ ELIEQRGTRL FPAKFDMQAA 101 QSALKHNIEE LGNVYKRELS KNNVTVYKGT AAFKDPHHVE IAQRGMKPFI 151 VEAKYIVVAT GSAVIQCPGV AIDNDKIISS DKALSLDYIP SRFTIMGGGT 201 IGLEIACIFN NLGSRVTIVE SQSEICQNMD NELASATKTL LQCQGIAFLL 251 DTRVQLAEAD AAGQLNITLL NKVSKKTYVH HCDVLMVSIG RRPLLKGLDI 301 SSIGLDERDF VENVDVQTQS LLKYPHIKPI GDVTLGPMLA LKAEEQAIRA 351 IQSIGCTGSD GTSNCGFPPN VLYCQPQIGW VGYTEEGLAK ARIPYQKGRV 401 LFSQNVRYNT LLPREENTTV SPFIKVLIDS RDMKILGVHM INDDANELLS 451 QASMAVSLGL TAHDVCKVPF PHPSLSESFK QAVQLAMANG TSPGVHVRE*

Amino Acid Sequence (or in FASTA format)

       1  MGGEDEILST MEDFAAVYDV LVIGCGPGGF TAAMQASQAG LLTACVDQRA
      51  SLGGAYLVDG AVPSKTLLYE SYLYRLLQQQ ELIEQRGTRL FPAKFDMQAA
     101  QSALKHNIEE LGNVYKRELS KNNVTVYKGT AAFKDPHHVE IAQRGMKPFI
     151  VEAKYIVVAT GSAVIQCPGV AIDNDKIISS DKALSLDYIP SRFTIMGGGT
     201  IGLEIACIFN NLGSRVTIVE SQSEICQNMD NELASATKTL LQCQGIAFLL
     251  DTRVQLAEAD AAGQLNITLL NKVSKKTYVH HCDVLMVSIG RRPLLKGLDI
     301  SSIGLDERDF VENVDVQTQS LLKYPHIKPI GDVTLGPMLA LKAEEQAIRA
     351  IQSIGCTGSD GTSNCGFPPN VLYCQPQIGW VGYTEEGLAK ARIPYQKGRV
     401  LFSQNVRYNT LLPREENTTV SPFIKVLIDS RDMKILGVHM INDDANELLS
     451  QASMAVSLGL TAHDVCKVPF PHPSLSESFK QAVQLAMANG TSPGVHVRE*

external links for Irc15p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Irc15p

1)	Alvaro D, et al. (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222
4)	Keyes BE and Burke DJ (2009) Irc15 Is a microtubule-associated protein that regulates microtubule dynamics in Saccharomyces cerevisiae. Curr Biol 19(6):472-8
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41