RRP12/YPL012W Protein Information Help

Standard Name Rrp12p 1
Systematic Name Ypl012wp
ORF Classification Verified
Description Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats (1, 2, 3)
Name Description Ribosomal RNA Processing 1
Experimental Data
Molecules/cell 8170 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,228
Molecular Weight (Da) 137,507
Isoelectric Point (pI) 7

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rrp12p (InterPro)
Physical Interactions There are 164 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052FD9 | Q12754
MIPS: YPL012W
NCBI: 1314064 | 6325245 | 683778 | 74676637 | 965081 | NP_015313.1 | NM_001183826.1
GenBank/EMBL/DDBJ: DAA11416.1 | U33335 | Z48483 | Z71255
Amino Acid Sequence (or in FASTA format)
 
       1  MDQDKVAFLL ELEDKLAKIR SQVNSKLENQ KHIAIILTAV EENIAGQATN
      51  DVSKNIVNYI ISFMSLLDQA VDPSTHEIKD IQLASSSTYL LDLIFHYSPK
     101  VLLRSKFSEI LTKIAPCITA EKANAPLIRA AIGCLESLLI AQDAQAWNNT
     151  YDLNVTPKRG LQGILELSLD VRPKVRKRAL DAVHAVLLNP PVAPTAEHVA
     201  AVFVADFCDK QLAGILNDLS NLSNKQLKAQ KTKEDINASV MRSLRLITSV
     251  VSTGQWPSSQ IEPLCDVLLG VTKSSEQYLV SASFECFESM FKTMAETTIS
     301  SGLAENKYLR VLDTIFALKP SNVDTLLTKS WIAVVIKGMS TYATHQPLKA
     351  LRKIPGVFHI MCTYLASETP EVYQAASQCL ISILSESVKD DLLLYTPSVD
     401  EKVFKNVDEI ISQIAKTFID FLSIRYSHCS REILKILVAA FNKFRYRSNP
     451  HFLKSLKIVD TWRVNEEQFM DLRNEIELVI GASISAMGPE MILAEAPLNL
     501  DNPSSERPGR AWLLPLIRDY TKNANLATFQ NELAPYIKSF QSKFDKVPEE
     551  SIQLRVFQTI VDQIWSTLPR FCELPMDLRE SFTDEFASEL SSLLYSEVEL
     601  RTTICHALKV LAESNVSYAE ESSSHNVLLL QRFPISEAQK NIEYLSTKST
     651  NLLAVLFNVY TQTTPNARSY ILETIDQYLK ITSKEDLEKT FNNVCGLLKN
     701  SMNEESSGNV NKEKKKPQLT ATLLDLIICM ITYLPVSSYS ALFSMFSLTV
     751  NSADALIQKR AYRIITKLSE LKSGSTAVAQ FISDIENVMV DSASSVQTSA
     801  KAARLTAIKT IVELLPLDHL DFIVRTVAEV ILSTKDVNEK SRETAFDTLI
     851  CMGRKMNEPN GIIKLFQIPG YDPTTPDQSS SISEFFKIIS AGLIGESQHM
     901  VSSSITGYAC LVFEFKNELD SGILMDIYDT IELYLTSNSR EIVKSAIGFT
     951  KVCVLGLPEE LMRPKVPELL LKLLRWSHEH TGHFKAKVKH IIERLIRRFG
    1001  YDYIEANFPE EDRRLLTNIR KMRNRNKRKD EEVTTGVSDV AATKGSRFMS
    1051  AFDEAVYGSD EENDNGSDQE ENVAGGKMKN GAKQFIVESG DNPLDLLDSQ
    1101  TLAHISSTRP KKFNKNQNRA RFNDDAFNFD SEGKLVVKGQ PKPSTNVDDP
    1151  LSAVTSGINA YLEAVKSGPV RGQRNKLKFR KNGKDSDEFG DDDDGEKDSR
    1201  LMRGRVNQGN KIGKHNKKGP KFKSRKKL*

external links for Rrp12p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome

YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Rrp12p
1) Fatica A and Tollervey D  (2002) Making ribosomes. Curr Opin Cell Biol 14(3):313-8
2) Oeffinger M, et al.  (2004) A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits. Genes Dev 18(2):196-209
3) Dosil M  (2011) Ribosome synthesis-unrelated functions of the preribosomal factor Rrp12 in cell cycle progression and the DNA damage response. Mol Cell Biol 31(12):2422-38
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41