TFC8/YPL007C Protein Information

Standard Name	Tfc8p 1
Systematic Name	Ypl007cp
ORF Classification	Verified
Description	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 (2, 3, 4)
Name Description	Transcription Factor C 1
Gene Product	tau 60 5

Experimental Data
Molecules/cell	2070 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	588
Molecular Weight (Da)	67,683
Isoelectric Point (pI)	6.18

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tfc8p (InterPro)
Physical Interactions	There are 24 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052E29 \| Q12308 MIPS: YPL007C NCBI: 118138572 \| 118138574 \| 1314069 \| 6325250 \| 683783 \| 74676578 \| 965086 \| NP_015318.1 GenBank/EMBL/DDBJ: DAA11421.1 \| U33335 \| Z48483 \| Z71255

Amino Acid Sequence (or in FASTA format)
1 MKLLKDLLVD RKEFEDWKNN LTWARDGTLY LTTFPDISIG QPKYAKDINC 51 NSKNLFHVKE FPLEFENKLD FELAQQNGLL NSQPVCYPRV CKPSPIDDWM 101 AVLSNNGNVS VFKDNKMLTN LDSKGNLSSR TYHCFEWNPI ESSIVVGNED 151 GELQFFSIRK NSENTPEFYF ESSIRLSDAG SKDWVTHIVW YEDVLVAALS 201 NNSVFSMTVS ASSHQPVSRM IQNASRRKIT DLKIVDYKVV LTCPGYVHKI 251 DLKNYSISSL KTGSLENFHI IPLNHEKEST ILLMSNKTSY KVLLEDELHV 301 TADNIIAPYL EKKFKKWSTI WNEFNNYETT LVIHGISLSP DGYSIAIVYD 351 MERVAFKYKI ASEQSFNIMF APLYHTWTIS ERAVGLAWYQ TYQIYNQSLP 401 KLPENFSMNK KLLNGNYPIS LDFQSYLNAL MKSEEMRIIM FLNMTIDKPS 451 ILSFLEALYE YAINKKSELT NSFDLACVLS IAAILKREAP IYNGTLLMKN 501 SFLEETFNLE SFTADPETVT STTNNTWKRC GVTLLPILTT HVKICPVSKQ 551 RVIDIKRDDL NDYGWFTRGL LERFNEISVY CGTTLEVM*

Amino Acid Sequence (or in FASTA format)

       1  MKLLKDLLVD RKEFEDWKNN LTWARDGTLY LTTFPDISIG QPKYAKDINC
      51  NSKNLFHVKE FPLEFENKLD FELAQQNGLL NSQPVCYPRV CKPSPIDDWM
     101  AVLSNNGNVS VFKDNKMLTN LDSKGNLSSR TYHCFEWNPI ESSIVVGNED
     151  GELQFFSIRK NSENTPEFYF ESSIRLSDAG SKDWVTHIVW YEDVLVAALS
     201  NNSVFSMTVS ASSHQPVSRM IQNASRRKIT DLKIVDYKVV LTCPGYVHKI
     251  DLKNYSISSL KTGSLENFHI IPLNHEKEST ILLMSNKTSY KVLLEDELHV
     301  TADNIIAPYL EKKFKKWSTI WNEFNNYETT LVIHGISLSP DGYSIAIVYD
     351  MERVAFKYKI ASEQSFNIMF APLYHTWTIS ERAVGLAWYQ TYQIYNQSLP
     401  KLPENFSMNK KLLNGNYPIS LDFQSYLNAL MKSEEMRIIM FLNMTIDKPS
     451  ILSFLEALYE YAINKKSELT NSFDLACVLS IAAILKREAP IYNGTLLMKN
     501  SFLEETFNLE SFTADPETVT STTNNTWKRC GVTLLPILTT HVKICPVSKQ
     551  RVIDIKRDDL NDYGWFTRGL LERFNEISVY CGTTLEVM*

external links for Tfc8p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Tfc8p

1)	Deprez E, et al. (1999) A subunit of yeast TFIIIC participates in the recruitment of TATA-binding protein. Mol Cell Biol 19(12):8042-51
2)	Conesa C, et al. (1993) On the subunit composition, stoichiometry, and phosphorylation of the yeast transcription factor TFIIIC/tau. J Biol Chem 268(24):18047-52
3)	Geiduschek EP and Kassavetis GA (2001) The RNA polymerase III transcription apparatus. J Mol Biol 310(1):1-26
4)	Schultz P, et al. (1989) The two DNA-binding domains of yeast transcription factor tau as observed by scanning transmission electron microscopy. EMBO J 8(12):3815-24
5)	Jourdain S, et al. (2003) The tau95 subunit of yeast TFIIIC influences upstream and downstream functions of TFIIIC.DNA complexes. J Biol Chem 278(12):10450-7
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41