AEP3/YPL005W Protein Information

Standard Name	Aep3p
Systematic Name	Ypl005wp
ORF Classification	Verified
Description	Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA (1, 2)
Name Description	ATPase ExPression 1

Experimental Data
Molecules/cell	1760 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	606
Molecular Weight (Da)	70,309
Isoelectric Point (pI)	10.53

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Aep3p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006C2D4 \| Q12089 MIPS: YPL005W NCBI: 1314071 \| 51012769 \| 6325252 \| 683785 \| 74676520 \| 965088 \| NP_015320.1 GenBank/EMBL/DDBJ: DAA11423.1 \| AY692659 \| U33335 \| Z48483 \| Z71255

Amino Acid Sequence (or in FASTA format)
1 MNTLRCLTQA LSKSGREAPK LYQKVIFPGL FREGIPIANV KKVDEKIIDS 51 PTSTSVNGEA KKIVRHGVKY EREQVKEYLS SLPTLTLSRK QIRDDYDEER 101 AKRMYMFSKQ TNSSNKFQKL LTAKSQEFTR ELLTLLIDCT SNEKNSGPER 151 FTRKFLKFSN DEIPPLPDFS KNPQLFENYI GILSHTKFNF RSSSKLNGIV 201 RKMLRHLLHP TNKTTLPLRS AQVYNDSIYF FSEHFDFASC REIFAQMKAE 251 GTKPNTITFN LLLRNVVKNS HIRKTKHPDD EVLFYLRSMR NHGVFADVIT 301 WTTCYNFLRD EVSRQLYIVQ MGEHLGNFNV NFVYTVLRNG DYRAEDCLKV 351 LAANSLPISR KTFYLCIERL LNEEQLETAS KLLDYGFQHL KSNFKLDSEA 401 MNHFMRVFAN KGRSDLAFLC YNTCRKIYKI KPDSQTFEML FKALVRNGNT 451 KNFGAVLQYI KDLKVSEGFG LRTSYWRTKA DSIFKFGSPN TLSEKSIEKA 501 RKLLGNLIAS EGEFSWKIWK ESDSSQKKIL RFLGCIPTTL RCTNTAQDHQ 551 KPTNLPSNIS QKKREYRNRV KAIATKAALE KRMAYIKDND VAFKKELVKR 601 RIVGEV*

Amino Acid Sequence (or in FASTA format)

       1  MNTLRCLTQA LSKSGREAPK LYQKVIFPGL FREGIPIANV KKVDEKIIDS
      51  PTSTSVNGEA KKIVRHGVKY EREQVKEYLS SLPTLTLSRK QIRDDYDEER
     101  AKRMYMFSKQ TNSSNKFQKL LTAKSQEFTR ELLTLLIDCT SNEKNSGPER
     151  FTRKFLKFSN DEIPPLPDFS KNPQLFENYI GILSHTKFNF RSSSKLNGIV
     201  RKMLRHLLHP TNKTTLPLRS AQVYNDSIYF FSEHFDFASC REIFAQMKAE
     251  GTKPNTITFN LLLRNVVKNS HIRKTKHPDD EVLFYLRSMR NHGVFADVIT
     301  WTTCYNFLRD EVSRQLYIVQ MGEHLGNFNV NFVYTVLRNG DYRAEDCLKV
     351  LAANSLPISR KTFYLCIERL LNEEQLETAS KLLDYGFQHL KSNFKLDSEA
     401  MNHFMRVFAN KGRSDLAFLC YNTCRKIYKI KPDSQTFEML FKALVRNGNT
     451  KNFGAVLQYI KDLKVSEGFG LRTSYWRTKA DSIFKFGSPN TLSEKSIEKA
     501  RKLLGNLIAS EGEFSWKIWK ESDSSQKKIL RFLGCIPTTL RCTNTAQDHQ
     551  KPTNLPSNIS QKKREYRNRV KAIATKAALE KRMAYIKDND VAFKKELVKR
     601  RIVGEV*

external links for Aep3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Aep3p

1)	Ellis TP, et al. (2004) Aep3p stabilizes the mitochondrial bicistronic mRNA encoding subunits 6 and 8 of the H+-translocating ATP synthase of Saccharomyces cerevisiae. J Biol Chem 279(16):15728-33
2)	Lee C, et al. (2009) Yeast AEP3p is an accessory factor in initiation of mitochondrial translation. J Biol Chem 284(49):34116-25
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41