HAT1/YPL001W Protein Information Help

Standard Name Hat1p 1
Systematic Name Ypl001wp
ORF Classification Verified
Description Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair (1, 2, 3, 4, 5, 6)
Name Description Histone AcetylTransferase 1
Gene Product KAT1 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 374
Molecular Weight (Da) 43,872
Isoelectric Point (pI) 5.14

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hat1p (InterPro)
Physical Interactions There are 102 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530B2 | Q12341
MIPS: YPL001W
NCBI: 1314075 | 157830412 | 2498433 | 45269974 | 6325256 | 683789 | 965092 | NP_015324.1 | NM_001183815.1
GenBank/EMBL/DDBJ: AAB68104.1 | AAS56368.1 | CAA88385.1 | CAA95040.1 | DAA11427.1 | AY558042 | U33335 | Z48483 | Z71255
External Classifications EC: 2.3.1.48 [Histone acetyltransferase]
Amino Acid Sequence (or in FASTA format)
       1  MSANDFKPET WTSSANEALR VSIVGENAVQ FSPLFTYPIY GDSEKIYGYK
      51  DLIIHLAFDS VTFKPYVNVK YSAKLGDDNI VDVEKKLLSF LPKDDVIVRD
     101  EAKWVDCFAE ERKTHNLSDV FEKVSEYSLN GEEFVVYKSS LVDDFARRMH
     151  RRVQIFSLLF IEAANYIDET DPSWQIYWLL NKKTKELIGF VTTYKYWHYL
     201  GAKSFDEDID KKFRAKISQF LIFPPYQNKG HGSCLYEAII QSWLEDKSIT
     251  EITVEDPNEA FDDLRDRNDI QRLRKLGYDA VFQKHSDLSD EFLESSRKSL
     301  KLEERQFNRL VEMLLLLNNS PSFELKVKNR LYIKNYDALD QTDPEKAREA
     351  LQNSFILVKD DYRRIIESIN KSQG*                           

external links for Hat1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) CYC2008 (complexes) MIPS YeastGFP
Candida (CGD) Complexome Pfam domains YeastRC Public Image Repository
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Hat1p
1) Kleff S, et al.  (1995) Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem 270(42):24674-7
2) Dutnall RN, et al.  (1998) Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell 94(4):427-38
3) Ruiz-Garcia AB, et al.  (1998) HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4. J Biol Chem 273(20):12599-605
4) Parthun MR, et al.  (1996) The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87(1):85-94
5) Kelly TJ, et al.  (2000) Type B histone acetyltransferase Hat1p participates in telomeric silencing. Mol Cell Biol 20(19):7051-8
6) Qin S and Parthun MR  (2002) Histone H3 and the histone acetyltransferase Hat1p contribute to DNA double-strand break repair. Mol Cell Biol 22(23):8353-65
7) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6