PHR1/YOR386W Protein Information

Standard Name	Phr1p 1
Systematic Name	Yor386wp
ORF Classification	Verified
Description	DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p (2, 3, 4)
Name Description	PHotoreactivation Repair deficient

Experimental Data
Molecules/cell	688 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	565
Molecular Weight (Da)	66,273
Isoelectric Point (pI)	9.9

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Phr1p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001319FE \| P05066 MIPS: YOR386W NCBI: 130158 \| 1420831 \| 172170 \| 4176 \| 6324962 \| NP_015031.1 \| NM_001183806.1 GenBank/EMBL/DDBJ: DAA11145.1 \| M11578 \| X03183 \| Z75294
External Classifications	EC: 4.1.99.3 [Deoxyribodipyrimidine photo-lyase]

Amino Acid Sequence (or in FASTA format)
1 MKRTVISSSN AYASKRSRLD IEHDFEQYHS LNKKYYPRPI TRTGANQFNN 51 KSRAKPMEIV EKLQKKQKTS FENVSTVMHW FRNDLRLYDN VGLYKSVALF 101 QQLRQKNAKA KLYAVYVINE DDWRAHMDSG WKLMFIMGAL KNLQQSLAEL 151 HIPLLLWEFH TPKSTLSNSK EFVEFFKEKC MNVSSGTGTI ITANIEYQTD 201 ELYRDIRLLE NEDHRLQLKY YHDSCIVAPG LITTDRGTNY SVFTPWYKKW 251 VLYVNNYKKS TSEICHLHII EPLKYNETFE LKPFQYSLPD EFLQYIPKSK 301 WCLPDVSEEA ALSRLKDFLG TKSSKYNNEK DMLYLGGTSG LSVYITTGRI 351 STRLIVNQAF QSCNGQIMSK ALKDNSSTQN FIKEVAWRDF YRHCMCNWPY 401 TSMGMPYRLD TLDIKWENNP VAFEKWCTGN TGIPIVDAIM RKLLYTGYIN 451 NRSRMITASF LSKNLLIDWR WGERWFMKHL IDGDSSSNVG GWGFCSSTGI 501 DAQPYFRVFN MDIQAKKYDP QMIFVKQWVP ELISSENKRP ENYPKPLVDL 551 KHSRERALKV YKDAM*

Amino Acid Sequence (or in FASTA format)

       1  MKRTVISSSN AYASKRSRLD IEHDFEQYHS LNKKYYPRPI TRTGANQFNN
      51  KSRAKPMEIV EKLQKKQKTS FENVSTVMHW FRNDLRLYDN VGLYKSVALF
     101  QQLRQKNAKA KLYAVYVINE DDWRAHMDSG WKLMFIMGAL KNLQQSLAEL
     151  HIPLLLWEFH TPKSTLSNSK EFVEFFKEKC MNVSSGTGTI ITANIEYQTD
     201  ELYRDIRLLE NEDHRLQLKY YHDSCIVAPG LITTDRGTNY SVFTPWYKKW
     251  VLYVNNYKKS TSEICHLHII EPLKYNETFE LKPFQYSLPD EFLQYIPKSK
     301  WCLPDVSEEA ALSRLKDFLG TKSSKYNNEK DMLYLGGTSG LSVYITTGRI
     351  STRLIVNQAF QSCNGQIMSK ALKDNSSTQN FIKEVAWRDF YRHCMCNWPY
     401  TSMGMPYRLD TLDIKWENNP VAFEKWCTGN TGIPIVDAIM RKLLYTGYIN
     451  NRSRMITASF LSKNLLIDWR WGERWFMKHL IDGDSSSNVG GWGFCSSTGI
     501  DAQPYFRVFN MDIQAKKYDP QMIFVKQWVP ELISSENKRP ENYPKPLVDL
     551  KHSRERALKV YKDAM*

external links for Phr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Phr1p

1)	Link, A. and Olson, M. (1989) Personal Communication, Mortimer Map Edition 10
2)	Green G and MacQuillan AM (1980) Photorepair of ultraviolet-induced petite mutational damage in Saccharomyces cerevisiae requires the product of the PHR1 gene. J Bacteriol 144(2):826-9
3)	Schild D, et al. (1984) Cloning and mapping of Saccharomyces cerevisiae photoreactivation gene PHR1. Mol Cell Biol 4(9):1864-70
4)	Sebastian J and Sancar GB (1991) A damage-responsive DNA binding protein regulates transcription of the yeast DNA repair gene PHR1. Proc Natl Acad Sci U S A 88(24):11251-5
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41