FRE3/YOR381W Protein Information

Standard Name	Fre3p
Systematic Name	Yor381wp
ORF Classification	Verified
Description	Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels (1, 2, 3)
Name Description	Ferric REductase

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	711
Molecular Weight (Da)	80,589
Isoelectric Point (pI)	7.07

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Fre3p (InterPro)
Transmembrane Domains	There are 7 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004B8D7 \| Q08905 MIPS: YOR381W NCBI: 1420821 \| 3913674 \| 6324957 \| NP_015026.1 \| NM_001183801.1 GenBank/EMBL/DDBJ: DAA11139.1 \| Z75289
External Classifications	EC: 1.16.1.- EC: 1.16.1.7 [Ferric-chelate reductase (NADH)] TC: 1.A.20.5

Amino Acid Sequence (or in FASTA format)
1 MYWVLLCGSI LLCCLSGASA SPAKTKMYGK LPLVLTDACM GVLGEVTWEY 51 SSDDLYSSPA CTYEPALQSM LYCIYESLNE KGYSNRTFEK TFAAIKEDCA 101 YYTDNLQNMT NADFYNMLNN GTTYIIQYSE GSANLTYPIE MDAQVRENYY 151 YSYHGFYANY DIGHTYGGII CAYFVGVMIL ASILHYLSYT PFKTALFKQR 201 LVRYVRRYLT IPTIWGKHAS SFSYLKIFTG FLPTRSEGVI ILGYLVLHTV 251 FLAYGYQYDP YNLIFDSRRE QIARYVADRS GVLAFAHFPL IALFAGRNNF 301 LEFISGVKYT SFIMFHKWLG RMMFLDAVIH GAAYTSYSVF YKDWAASKEE 351 TYWQFGVAAL CIVGVMVFFS LAMFRKFFYE AFLFLHIVLG ALFFYTCWEH 401 VVELSGIEWI YAAIAIWTID RLIRIVRVSY FGFPKASLQL VGDDIIRVTV 451 KRPVRLWKAK PGQYVFVSFL HHLYFWQSHP FTVLDSIIKD GELTIILKEK 501 KGVTKLVKKY VCCNGGKASM RLAIEGPYGS SSPVNNYDNV LLLTGGTGLP 551 GPIAHAIKLG KTSAATGKQF IKLVIAVRGF NVLEAYKPEL MCLEDLNVQL 601 HIYNTMEVPA LTPNDSLEIS QQDEKADGKG VVMATTLEQS PNPVEFDGTV 651 FHHGRPNVEK LLHEVGDLNG SLAVVCCGPP VFVDEVRDQT ANLVLEKPAK 701 AIEYFEEYQS W*

Amino Acid Sequence (or in FASTA format)

       1  MYWVLLCGSI LLCCLSGASA SPAKTKMYGK LPLVLTDACM GVLGEVTWEY
      51  SSDDLYSSPA CTYEPALQSM LYCIYESLNE KGYSNRTFEK TFAAIKEDCA
     101  YYTDNLQNMT NADFYNMLNN GTTYIIQYSE GSANLTYPIE MDAQVRENYY
     151  YSYHGFYANY DIGHTYGGII CAYFVGVMIL ASILHYLSYT PFKTALFKQR
     201  LVRYVRRYLT IPTIWGKHAS SFSYLKIFTG FLPTRSEGVI ILGYLVLHTV
     251  FLAYGYQYDP YNLIFDSRRE QIARYVADRS GVLAFAHFPL IALFAGRNNF
     301  LEFISGVKYT SFIMFHKWLG RMMFLDAVIH GAAYTSYSVF YKDWAASKEE
     351  TYWQFGVAAL CIVGVMVFFS LAMFRKFFYE AFLFLHIVLG ALFFYTCWEH
     401  VVELSGIEWI YAAIAIWTID RLIRIVRVSY FGFPKASLQL VGDDIIRVTV
     451  KRPVRLWKAK PGQYVFVSFL HHLYFWQSHP FTVLDSIIKD GELTIILKEK
     501  KGVTKLVKKY VCCNGGKASM RLAIEGPYGS SSPVNNYDNV LLLTGGTGLP
     551  GPIAHAIKLG KTSAATGKQF IKLVIAVRGF NVLEAYKPEL MCLEDLNVQL
     601  HIYNTMEVPA LTPNDSLEIS QQDEKADGKG VVMATTLEQS PNPVEFDGTV
     651  FHHGRPNVEK LLHEVGDLNG SLAVVCCGPP VFVDEVRDQT ANLVLEKPAK
     701  AIEYFEEYQS W*

external links for Fre3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	TCDB
YOGY	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Fre3p

1)	Martins LJ, et al. (1998) Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae. J Biol Chem 273(37):23716-21
2)	Georgatsou E and Alexandraki D (1999) Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes. Yeast 15(7):573-84
3)	Yun CW, et al. (2001) The role of the FRE family of plasma membrane reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae. J Biol Chem 276(13):10218-23