PIP2/YOR363C Protein Information Help

Standard Name Pip2p
Systematic Name Yor363cp
Alias Oaf2p 1
ORF Classification Verified
Description Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication (2, 3, 4)
Name Description Peroxisome Induction Pathway 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 996
Molecular Weight (Da) 114,709
Isoelectric Point (pI) 7.49

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pip2p (InterPro)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000131AFE | P52960
MIPS: YOR363C
NCBI: 1177646 | 1420788 | 1730572 | 398366391 | NP_015008.3
GenBank/EMBL/DDBJ: DAA11124.1 | X91991 | Z75271
Amino Acid Sequence (or in FASTA format)
 
       1  MYFTDESSPA MNRVGKKRNR LSFVCQACRK AKTKCDQEKP RCGRCTKQNL
      51  FCIYDVARQA APRNPNKDAT IARLKKEIRY WRNKTVDLTQ EKKDFYTALK
     101  RPTEELAARR TCKSLQENSF PISLYKTHPR LIMTKVMKRE INPLSEKYLI
     151  FQDTFLKTLI ASVLLSCSRN SMIPALNADI SRSRTQPCVK NNVVKMREVL
     201  LKNSKYESQR KSINEFTDRL LQRKNPEEQI AVNKVISLLY SNRESSYLED
     251  TCPTENDYSD LLKGYINEIE KTLPPKAIIE QYLSHFFEHI FHLIPFASKE
     301  MLEESIHTTV QYNELGEVRL SMGTTLIRNK MENLCILLLI LRIAYISLTF
     351  IEDKIEDYSP YITKEMLEQY PIQSEVIFLA QQILASENWC ACANENTISC
     401  LLYIWCAFVF SPTEGDFLLE QPSDVIINLV ILIGTSIGLH RDPSDFPALN
     451  HPEASDKRLL NLRRIQWLSI ISMATLESSL KGRLLVSPLS MIDLFIDVRD
     501  PNCVEIYKKR VKKDLTGSES DEQLLEIHEI FFHRAQLALF LSDLNNITIS
     551  YSGSVPMDTL ETLRVKANEL LKNKFQLRSV DINIYDEEKT FQKLTFNSIL
     601  NSISLSGQIL GKLMMLRASI ALMLYFETLA MERSECLSFF YKYFFQCCAD
     651  TISLIRFFFL YFNGSYEKVL SSLVCFITTK VIQLAVPTTM FTLLVIIMRV
     701  ELAKNMLLVK CNECNARGDI SDLPEIKEKI KSLDTIKENF ERLLLEVYLL
     751  ASQNLRFKYF YIFKMLTLFD VFIQRLRKGQ LFSGLFVKVD KDLTTKKIAT
     801  MLELTLGINL DKSDHLIDRL KGKNLTVNFT LDQLYQIIKE FDRIKNIGVA
     851  DPQNSLNPSK PNMKDNTPTI ELLLNSSVEN ESVPPYSSSN DPTNVGNAST
     901  YSLAHNISNQ NNEENMPPSI GSSESNRAAP NLNFMPINNN YNNSGSNINN
     951  NDNVKLPSNF KNYYDPPMSS LDISMDVPDI FGSLDFFDYD LLFQND*

external links for Pip2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Pip2p
1) Karpichev IV, et al.  (1997) A complex containing two transcription factors regulates peroxisome proliferation and the coordinate induction of beta-oxidation enzymes in Saccharomyces cerevisiae. Mol Cell Biol 17(1):69-80
2) Rottensteiner H, et al.  (1996) Pip2p: a transcriptional regulator of peroxisome proliferation in the yeast Saccharomyces cerevisiae. EMBO J 15(12):2924-34
3) Rottensteiner H, et al.  (1997) A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Eur J Biochem 247(3):776-83
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61