MEK1/YOR351C Protein Information

Standard Name	Mek1p 1
Systematic Name	Yor351cp
Alias	Mre4p 2
ORF Classification	Verified
Description	Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids (1, 2, 3, 4, 5)
Name Description	MEiotic Kinase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	497
Molecular Weight (Da)	56,849
Isoelectric Point (pI)	7.83

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mek1p (InterPro)
Physical Interactions	There are 72 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012EEC5 \| P24719 MIPS: YOR351C NCBI: 1199853 \| 127299 \| 1420764 \| 3969 \| 398366345 \| 4002 \| NP_014996.3 GenBank/EMBL/DDBJ: DAA11112.1 \| X61208 \| X63112 \| X95720 \| Z75259
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MRPLYSCNLA TKDDIEMAGG VAPAHLEVNV GGYNTEQTIP IVKHQLVKVG 51 RNDKECQLVL TNPSISSVHC VFWCVFFDED SIPMFYVKDC SLNGTYLNGL 101 LLKRDKTYLL KHCDVIELSQ GSEENDIKKT RLVFMINDDL QSSLDPKLLD 151 QMGFLREVDQ WEITNRIVGN GTFGHVLITH NSKERDEDVC YHPENYAVKI 201 IKLKPNKFDK EARILLRLDH PNIIKVYHTF CDRNNHLYIF QDLIPGGDLF 251 SYLAKGDCLT SMSETESLLI VFQILQALNY LHDQDIVHRD LKLDNILLCT 301 PEPCTRIVLA DFGIAKDLNS NKERMHTVVG TPEYCAPEVG FRANRKAYQS 351 FSRAATLEQR GYDSKCDLWS LGVITHIMLT GISPFYGDGS ERSIIQNAKI 401 GKLNFKLKQW DIVSDNAKSF VKDLLQTDVV KRLNSKQGLK HIWIAKHLSQ 451 LERLYYKKIL CNNEGPKLES INSDWKRKLP KSVIISQAIP KKKKVLE*

Amino Acid Sequence (or in FASTA format)

       1  MRPLYSCNLA TKDDIEMAGG VAPAHLEVNV GGYNTEQTIP IVKHQLVKVG
      51  RNDKECQLVL TNPSISSVHC VFWCVFFDED SIPMFYVKDC SLNGTYLNGL
     101  LLKRDKTYLL KHCDVIELSQ GSEENDIKKT RLVFMINDDL QSSLDPKLLD
     151  QMGFLREVDQ WEITNRIVGN GTFGHVLITH NSKERDEDVC YHPENYAVKI
     201  IKLKPNKFDK EARILLRLDH PNIIKVYHTF CDRNNHLYIF QDLIPGGDLF
     251  SYLAKGDCLT SMSETESLLI VFQILQALNY LHDQDIVHRD LKLDNILLCT
     301  PEPCTRIVLA DFGIAKDLNS NKERMHTVVG TPEYCAPEVG FRANRKAYQS
     351  FSRAATLEQR GYDSKCDLWS LGVITHIMLT GISPFYGDGS ERSIIQNAKI
     401  GKLNFKLKQW DIVSDNAKSF VKDLLQTDVV KRLNSKQGLK HIWIAKHLSQ
     451  LERLYYKKIL CNNEGPKLES INSDWKRKLP KSVIISQAIP KKKKVLE*

external links for Mek1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Mek1p

1)	Rockmill B and Roeder GS (1991) A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Genes Dev 5(12B):2392-404
2)	Leem SH and Ogawa H (1992) The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 20(3):449-57
3)	Bailis JM, et al. (2000) Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins. Mol Cell Biol 20(13):4838-48
4)	Bailis JM and Roeder GS (2000) Pachytene exit controlled by reversal of Mek1-dependent phosphorylation. Cell 101(2):211-21
5)	Niu H, et al. (2007) Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis. Mol Cell Biol 27(15):5456-67