CIN1/YOR349W Protein Information Help

Standard Name Cin1p 1
Systematic Name Yor349wp
ORF Classification Verified
Description Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl (1, 2, 3)
Name Description Chromosome INstability 1
Experimental Data
Molecules/cell 704 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,014
Molecular Weight (Da) 116,647
Isoelectric Point (pI) 8.18

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cin1p (InterPro)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000531BF | P40987
MIPS: YOR349W
NCBI: 1199851 | 1420760 | 2326831 | 398366341 | 563615 | 729138 | NP_014994.3
GenBank/EMBL/DDBJ: DAA11110.1 | X95720 | Z46420 | Z75257 | Z75258
Amino Acid Sequence (or in FASTA format)
 
       1  MNNIRALLDS IQSGVQTVSP EKHQQTIAAI NKFQDDPALL DTILPRCVPL
      51  LTKSFFCMSQ RDQKLVAELF YNLDKISHSK VLKSLDTSIF RLNEILNYLQ
     101  DRASPSSFSD VLCVYLNLSW LSVILLSPYA FKDKFNKTLQ VSSRFENYPI
     151  CIPPINKIKA VLYFKNFTDA FDQLPEREQA NVPFLNQFLK LFIQSSEKAN
     201  YYFSNENLRH LQQVALSNDG IKLLPKLFQI SFNHGSHDIL DAIVEFFHDH
     251  LSSNSTDTRF QLAHSFAKIA KFLHQADPAS FIELIDYTIE NTVSLLQAPC
     301  DSIDSNELHT SLLIIAEVAL AKILPIDLVD RVLTLIIPKT CHFQKSHFQI
     351  IKGHHIRDST NFIIWSVIRS NRSNSLSPQV LQSLLSHLLI NAFFDPELII
     401  RYSSFAALQE LLGRSNKSLA LNQNDIALIL QANWKDLPRS FEENSGLIRR
     451  LFNPENTSKS AVCVWKVFRD WSFNWNLLEN LHLTTMKLNI DYNLVPLIKS
     501  KLSSPALLQE VLNKAGSSVT QNCQILYLYL KLFENDVNCP KISEICIDIY
     551  QKKIKFQLTT QAKRQFNDNS PELFQIFVIL KYWQLTGQND FNQELFWKFV
     601  DIVSPQKKLN LYNEFIPIIQ QIISQCVSLN YTRIVQLIKS DNELTCRSIC
     651  HMPDQEKMCS LFFSQFPLLS PQSRSLLIGE LDHHWDVRIS LLPSNSYRKF
     701  RNIIINCLDD YTITQQGDVG RLVRIQALKL MQSHPDFLSG DCDSINPKLT
     751  RLLAEPVPEI RKLSYQLLAS ATSQITVLSD SSILNFRHKQ GLSEEFWKGY
     801  AVSAGAIHFT DSQLTSSIDS FIVYYRSLSP SQQLELCHDL IRIIPSAKQI
     851  AESRIRDRNK DPLTGGMRFD TIKFTIHCVK FWTRIMESGL VVLHPNFNFQ
     901  GVFAKFYNLH LLDCTTLRVS VIKFFPFLAI SCYHTMRENA DQKNLSNIIL
     951  KRLLVLVKRE YAATKSKFMT DQNVALQGMF QIFLELGVTR QLQALQVACQ
    1001  KHELANILES DITL*

external links for Cin1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Cin1p
1) Stearns T, et al.  (1990) Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124(2):251-62
2) Hoyt MA, et al.  (1990) Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Mol Cell Biol 10(1):223-34
3) Tian G, et al.  (1996) Pathway leading to correctly folded beta-tubulin. Cell 86(2):287-96
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41