REV1/YOR346W Protein Information Help

Standard Name Rev1p 1, 2
Systematic Name Yor346wp
ORF Classification Verified
Description Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress (3, 4, 5, 6)
Name Description REVersionless 1
Experimental Data
Molecules/cell 521 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 985
Molecular Weight (Da) 112,226
Isoelectric Point (pI) 8.49

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rev1p (InterPro)
Physical Interactions There are 31 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001336E2 | P12689
MIPS: YOR346W
NCBI: 1199848 | 1420754 | 172385 | 210060900 | 2507536 | 328877263 | 436408925 | 436408926 | 442570309 | 6324921 | 78101426 | NP_014991.1
GenBank/EMBL/DDBJ: DAA11107.1 | M22222 | X95720 | Z75253
External Classifications EC: 2.7.7.- [Transferases transferring phosphorous-containing groups nucleotidyltransferases]
Amino Acid Sequence (or in FASTA format)
 
       1  MGEHGGLVDL LDSDLEYSIN RETPDKNNCL SQQSVNDSHL TAKTGGLNAR
      51  SFLSTLSDDS LIEYVNQLSQ TNKNNSNPTA GTLRFTTKNI SCDELHADLG
     101  GGEDSPIARS VIEIQESDSN GDDVKKNTVY TREAYFHEKA HGQTLQDQIL
     151  KDQYKDQISS QSSKIFKNCV IYINGYTKPG RLQLHEMIVL HGGKFLHYLS
     201  SKKTVTHIVA SNLPLKKRIE FANYKVVSPD WIVDSVKEAR LLPWQNYSLT
     251  SKLDEQQKKL DNCKTVNSIP LPSETSLHKG SKCVGSALLP VEQQSPVNLN
     301  NLEAKRIVAC DDPDFLTSYF AHSRLHHLSA WKANLKDKFL NENIHKYTKI
     351  TDKDTYIIFH IDFDCFFATV AYLCRSSSFS ACDFKRDPIV VCHGTKNSDI
     401  ASCNYVARSY GIKNGMWVSQ AEKMLPNGIK LISLPYTFEQ FQLKSEAFYS
     451  TLKRLNIFNL ILPISIDEAV CVRIIPDNIH NTNTLNARLC EEIRQEIFQG
     501  TNGCTVSIGC SDSLVLARLA LKMAKPNGYN ITFKSNLSEE FWSSFKLDDL
     551  PGVGHSTLSR LESTFDSPHS LNDLRKRYTL DALKASVGSK LGMKIHLALQ
     601  GQDDEESLKI LYDPKEVLQR KSLSIDINWG IRFKNITQVD LFIERGCQYL
     651  LEKLNEINKT TSQITLKLMR RCKDAPIEPP KYMGMGRCDS FSRSSRLGIP
     701  TNEFGIIATE MKSLYRTLGC PPMELRGLAL QFNKLVDVGP DNNQLKLRLP
     751  FKTIVTNRAF EALPEDVKND INNEFEKRNY KRKESGLTSN SLSSKKKGFA
     801  ISRLEVNDLP STMEEQFMNE LPTQIRAEVR HDLRIQKKIQ QTKLGNLQEK
     851  IKRREESLQN EKNHFMGQNS IFQPIKFQNL TRFKKICQLV KQWVAETLGD
     901  GGPHEKDVKL FVKYLIKLCD SNRVHLVLHL SNLISRELNL CAFLNQDHSG
     951  FQTWERILLN DIIPLLNRNK HTYQTVRKLD MDFEV*

external links for Rev1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Rev1p
1) Lemontt JF  (1971) Mutants of yeast defective in mutation induced by ultraviolet light. Genetics 68(1):21-33
2) Larimer, F.  (1989) Personal Communication, Mortimer Map Edition 10
3) Nelson JR, et al.  (1996) Deoxycytidyl transferase activity of yeast REV1 protein. Nature 382(6593):729-31
4) Larimer FW, et al.  (1989) The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysis. J Bacteriol 171(1):230-7
5) Haracska L, et al.  (2001) Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites. Genes Dev 15(8):945-54
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41