PDR10/YOR328W Protein Information

Standard Name	Pdr10p 1
Systematic Name	Yor328wp
ORF Classification	Verified
Description	ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p (2, 3, 4, 5)
Name Description	Pleiotropic Drug Resistance 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,564
Molecular Weight (Da)	176,459
Isoelectric Point (pI)	7.87

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pdr10p (InterPro)
Transmembrane Domains	There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 7 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001314DA \| P51533 MIPS: YOR328W NCBI: 1420717 \| 1709621 \| 2326829 \| 6324904 \| 861119 \| NP_014973.1 GenBank/EMBL/DDBJ: DAA11091.1 \| Z49821 \| Z75236 \| Z75237
External Classifications	TC: 3.A.1.205 [The Pleiotropic Drug Resistance (PDR) Family]

Amino Acid Sequence (or in FASTA format)
1 MLQAPSSSNS GLNQGNAAPD GPPNETQPYE GLDAAAQEEI KELARTLTSQ 51 SSLLSQEKRI TGTGDPNTLT AASSSSLSRS IFASDIKGVN PILLDVNDPD 101 YDETLDPRSE NFSSVRWVRN MAQICENDSD FYKPFSLGCA WKDLSASGDS 151 ADITYQGTFG NMPIKYLKMS WRCISRRLFH RTHGKSEDND SGFQILKPMD 201 GCINPGELLV VLGRPGAGCT TLLKSISVNT HGFKISPDTI ITYNGFSNKE 251 IKNHYRGEVV YNAESDIHIP HLTVFQTLYT VARLKTPRNR IKGVDRDTFA 301 KHMTEVAMAT YGLSHTADTK VGNDFVRGVS GGERKRVSIA EVSICGSKFQ 351 CWDNATRGLD SATALEFIKA LKTQATITKS AATVAIYQCS KDAYDLFDKV 401 CVLYDGYQIF FGPSKQAKKY FQRMGYVCPE RQTTADYLTS ITSPSERIKD 451 KDMVKHGIMI PQTAYEMNQY WIQSEEYKQL QVQVNKHLDT DSSQQREQIK 501 NAHIAKQSKR ARPSSPYTVS FFLQVKYILI RDIWRIKNDP SIQLFTVLSH 551 AAMALILGSM FYEVMLSTTT TTFYYRGAAI FFAILFNAFS SLLEIFSLYE 601 TRPITEKHKT YSLYRPSADA FASTFSDVPT KLATAVTFNI PYYFLINLKR 651 DAGAFFFYFL INIITVFAMS HLFRCIGSVS KTLPQAMVPA SVLLLAFAMY 701 TGFAIPRVQM LGWSKWISYI NPLSYLFESL MINEFHGRNF PCAQYIPSGP 751 NYVNATGDEV TCSALGSIPG NNYVSGDDFI QTNYGYRHKN KWRSVGIGLA 801 YIIFFLFLYL FFCEYNEGAK QNGEMLVFPH SVVKKMKKKG IVSEKKKKNQ 851 PTLSTSDAEK DVEMNNNSSA TDSRFLRDSD AAIMGNDKTV AKEHYSSPSS 901 SASQSNSFSK SDDIELSKSQ AIFHWKNLCY DIPIKNGKRR ILDNVDGWVK 951 PGTLTALIGA SGAGKTTLLD CLAERTTMGL ITGDVFVDGR PRDQSFPRSI 1001 GYCQQQDLHL KTATVRESLR FSAYLRQADD VSIEEKDKYV EEVIEVLEMK 1051 LYADAIVGVP GEGLNVEQRK RLTIGVELAA KPKLLVFLDE PTSGLDSQTA 1101 WSTCQLMKKL ASRGQAILCT IHQPSALLMQ EFDRLLFLQE GGQTVYFGEL 1151 GKGCKTMINY FEAHGAHKCP PDANPAEWML EIVGAAPGTH ASQDYFAIWR 1201 DSEEYREMQK ELDWMERELP KRTEGSSNEE QKEFATSTLY QIKLVSYRLF 1251 HQYWRTPFYL WSKFFSTIVS ELFIGFTFFK ANTSLQGLQN QMLAIFMFTV 1301 VFNPILQQYL PLFVQQRELY EARERPSRTF SWKAFIVSQI LVEIPWNLLA 1351 GTIAFFVYYY PVGFYRNASY ANQLHERGAL FWLFACAFYV YISSMGVLVI 1401 SCIEIAENAA NLASLFFIMS LSFCGVLATP NILPRFWIFM YRVSPLTYLI 1451 DALLSVGLAN ASVVCSSNEL LKIVPPSGMT CSEYMEPYMQ STGTGYLLDG 1501 SSETECHFCQ FSSTNDYLAT VSSSYSRRWM NYGIFSAYIV FDYCAAIFLY 1551 WLVRVPKKSK KLKK*

Amino Acid Sequence (or in FASTA format)

       1  MLQAPSSSNS GLNQGNAAPD GPPNETQPYE GLDAAAQEEI KELARTLTSQ
      51  SSLLSQEKRI TGTGDPNTLT AASSSSLSRS IFASDIKGVN PILLDVNDPD
     101  YDETLDPRSE NFSSVRWVRN MAQICENDSD FYKPFSLGCA WKDLSASGDS
     151  ADITYQGTFG NMPIKYLKMS WRCISRRLFH RTHGKSEDND SGFQILKPMD
     201  GCINPGELLV VLGRPGAGCT TLLKSISVNT HGFKISPDTI ITYNGFSNKE
     251  IKNHYRGEVV YNAESDIHIP HLTVFQTLYT VARLKTPRNR IKGVDRDTFA
     301  KHMTEVAMAT YGLSHTADTK VGNDFVRGVS GGERKRVSIA EVSICGSKFQ
     351  CWDNATRGLD SATALEFIKA LKTQATITKS AATVAIYQCS KDAYDLFDKV
     401  CVLYDGYQIF FGPSKQAKKY FQRMGYVCPE RQTTADYLTS ITSPSERIKD
     451  KDMVKHGIMI PQTAYEMNQY WIQSEEYKQL QVQVNKHLDT DSSQQREQIK
     501  NAHIAKQSKR ARPSSPYTVS FFLQVKYILI RDIWRIKNDP SIQLFTVLSH
     551  AAMALILGSM FYEVMLSTTT TTFYYRGAAI FFAILFNAFS SLLEIFSLYE
     601  TRPITEKHKT YSLYRPSADA FASTFSDVPT KLATAVTFNI PYYFLINLKR
     651  DAGAFFFYFL INIITVFAMS HLFRCIGSVS KTLPQAMVPA SVLLLAFAMY
     701  TGFAIPRVQM LGWSKWISYI NPLSYLFESL MINEFHGRNF PCAQYIPSGP
     751  NYVNATGDEV TCSALGSIPG NNYVSGDDFI QTNYGYRHKN KWRSVGIGLA
     801  YIIFFLFLYL FFCEYNEGAK QNGEMLVFPH SVVKKMKKKG IVSEKKKKNQ
     851  PTLSTSDAEK DVEMNNNSSA TDSRFLRDSD AAIMGNDKTV AKEHYSSPSS
     901  SASQSNSFSK SDDIELSKSQ AIFHWKNLCY DIPIKNGKRR ILDNVDGWVK
     951  PGTLTALIGA SGAGKTTLLD CLAERTTMGL ITGDVFVDGR PRDQSFPRSI
    1001  GYCQQQDLHL KTATVRESLR FSAYLRQADD VSIEEKDKYV EEVIEVLEMK
    1051  LYADAIVGVP GEGLNVEQRK RLTIGVELAA KPKLLVFLDE PTSGLDSQTA
    1101  WSTCQLMKKL ASRGQAILCT IHQPSALLMQ EFDRLLFLQE GGQTVYFGEL
    1151  GKGCKTMINY FEAHGAHKCP PDANPAEWML EIVGAAPGTH ASQDYFAIWR
    1201  DSEEYREMQK ELDWMERELP KRTEGSSNEE QKEFATSTLY QIKLVSYRLF
    1251  HQYWRTPFYL WSKFFSTIVS ELFIGFTFFK ANTSLQGLQN QMLAIFMFTV
    1301  VFNPILQQYL PLFVQQRELY EARERPSRTF SWKAFIVSQI LVEIPWNLLA
    1351  GTIAFFVYYY PVGFYRNASY ANQLHERGAL FWLFACAFYV YISSMGVLVI
    1401  SCIEIAENAA NLASLFFIMS LSFCGVLATP NILPRFWIFM YRVSPLTYLI
    1451  DALLSVGLAN ASVVCSSNEL LKIVPPSGMT CSEYMEPYMQ STGTGYLLDG
    1501  SSETECHFCQ FSSTNDYLAT VSSSYSRRWM NYGIFSAYIV FDYCAAIFLY
    1551  WLVRVPKKSK KLKK*

external links for Pdr10p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	TCDB
	GeneMANIA	YeastRC Structure Prediction (Seattle)

References cited on this page View Complete Literature Guide for Pdr10p

1)	Parle, A.G., et al. (1995) PDR10, a candidate pleiotropic drug resistance locus encoding a new ABC transporter in Saccharomyces cerevisiae. Unpublished
2)	Parle-McDermott AG, et al. (1996) Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I. Yeast 12(10B Suppl):999-1004
3)	Decottignies A, et al. (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. J Biol Chem 273(20):12612-22
4)	Wolfger H, et al. (1997) The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. FEBS Lett 418(3):269-74
5)	Balzi E and Goffeau A (1995) Yeast multidrug resistance: the PDR network. J Bioenerg Biomembr 27(1):71-6