PRO2/YOR323C Protein Information

Standard Name	Pro2p
Systematic Name	Yor323cp
ORF Classification	Verified
Description	Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis (1)
Name Description	PROline requiring

Experimental Data
Molecules/cell	6920 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	456
Molecular Weight (Da)	49,740
Isoelectric Point (pI)	5.33

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pro2p (InterPro)
Physical Interactions	There are 18 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000531D1 \| P54885 MIPS: YOR323C NCBI: 1171206 \| 1420708 \| 1709784 \| 51013419 \| 52696231 \| 52696232 \| 6324899 \| 940855 \| NP_014968.1 GenBank/EMBL/DDBJ: DAA11087.1 \| AY692984 \| U43565 \| X90565 \| Z75231
External Classifications	EC: 1.2.1.41 [Glutamate-5-semialdehyde dehydrogenase]

Amino Acid Sequence (or in FASTA format)
1 MSSSQQIAKN ARKAGNILKT ISNEGRSDIL YKIHDALKAN AHAIEEANKI 51 DLAVAKETGL ADSLLKRLDL FKGDKFEVML QGIKDVAELE DPVGKVKMAR 101 ELDDGLTLYQ VTAPVGVLLV IFESRPEVIA NITALSIKSG NAAILKGGKE 151 SVNTFREMAK IVNDTIAQFQ SETGVPVGSV QLIETRQDVS DLLDQDEYID 201 LVVPRGSNAL VRKIKDTTKI PVLGHADGIC SIYLDEDADL IKAKRISLDA 251 KTNYPAGCNA METLLINPKF SKWWEVLENL TLEGGVTIHA TKDLKTAYFD 301 KLNELGKLTE AIQCKTVDAD EEQDFDKEFL SLDLAAKFVT STESAIQHIN 351 THSSRHTDAI VTENKANAEK FMKGVDSSGV YWNASTRFAD GFRYGFGAEV 401 GISTSKIHAR GPVGLDGLVS YQYQIRGDGQ VASDYLGAGG NKAFVHKDLD 451 IKTVTL*

Amino Acid Sequence (or in FASTA format)

       1  MSSSQQIAKN ARKAGNILKT ISNEGRSDIL YKIHDALKAN AHAIEEANKI
      51  DLAVAKETGL ADSLLKRLDL FKGDKFEVML QGIKDVAELE DPVGKVKMAR
     101  ELDDGLTLYQ VTAPVGVLLV IFESRPEVIA NITALSIKSG NAAILKGGKE
     151  SVNTFREMAK IVNDTIAQFQ SETGVPVGSV QLIETRQDVS DLLDQDEYID
     201  LVVPRGSNAL VRKIKDTTKI PVLGHADGIC SIYLDEDADL IKAKRISLDA
     251  KTNYPAGCNA METLLINPKF SKWWEVLENL TLEGGVTIHA TKDLKTAYFD
     301  KLNELGKLTE AIQCKTVDAD EEQDFDKEFL SLDLAAKFVT STESAIQHIN
     351  THSSRHTDAI VTENKANAEK FMKGVDSSGV YWNASTRFAD GFRYGFGAEV
     401  GISTSKIHAR GPVGLDGLVS YQYQIRGDGQ VASDYLGAGG NKAFVHKDLD
     451  IKTVTL*

external links for Pro2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Pro2p

1)	Tomenchok DM and Brandriss MC (1987) Gene-enzyme relationships in the proline biosynthetic pathway of Saccharomyces cerevisiae. J Bacteriol 169(12):5364-72
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41