MCH5/YOR306C Protein Information

Standard Name	Mch5p 1
Systematic Name	Yor306cp
ORF Classification	Verified
Description	Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport (1, 2)
Name Description	MonoCarboxylate transporter Homologue 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	521
Molecular Weight (Da)	57,582
Isoelectric Point (pI)	5.41

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mch5p (InterPro)
Transmembrane Domains	There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0001F7BD63 \| Q08777 MIPS: YOR306C NCBI: 1420675 \| 347595675 \| 398366189 \| NP_014951.4 GenBank/EMBL/DDBJ: DAA11072.2 \| Z75214

Amino Acid Sequence (or in FASTA format)
1 MSSDSLTPKD TIVPEEQTNQ LRQPDLDEDS IHYDPEADDL ESLETTASYA 51 STSVSAKVYT KKEVNKGTDI ESQPHWGENT SSTHDSDKEE DSNEEIESFP 101 EGGFKAWVVT FGCFLGLIAC FGLLNSTGVI ESHLQDNQLS SESVSTIGWL 151 FSLFLFVCSA SCIISGTYFD RNGFRTIMIV GTVFHVAGLF ATANSTKYWH 201 FILSFAIVCG FGNGIVLSPL VSVPAHYFFK RRGTALAMAT IGGSVGGVVF 251 PIMLRSFFSM KSDTDPTYGF VWGIRTLGFL DLALLTLSII LVKERLPHVI 301 ENSKDGESRW RYILRVYILQ CFDAKAFLDM KYLFCVLGTV FSELSINSAL 351 TYYGSYATSH GISANDAYTL IMIINVCGIP GRWVPGYLSD KFGRFNVAIA 401 TLLTLFIVMF VGWLPFGTNL TNMYVISALY GFCSGSVFSL LPVCCGQISK 451 TEEFGKRYST MYFVVGFGTL VGIPITGAII SIKTTADYQH YIIFCGLATF 501 VSAVCYIISR AYCVGFKWVR F*

Amino Acid Sequence (or in FASTA format)

       1  MSSDSLTPKD TIVPEEQTNQ LRQPDLDEDS IHYDPEADDL ESLETTASYA
      51  STSVSAKVYT KKEVNKGTDI ESQPHWGENT SSTHDSDKEE DSNEEIESFP
     101  EGGFKAWVVT FGCFLGLIAC FGLLNSTGVI ESHLQDNQLS SESVSTIGWL
     151  FSLFLFVCSA SCIISGTYFD RNGFRTIMIV GTVFHVAGLF ATANSTKYWH
     201  FILSFAIVCG FGNGIVLSPL VSVPAHYFFK RRGTALAMAT IGGSVGGVVF
     251  PIMLRSFFSM KSDTDPTYGF VWGIRTLGFL DLALLTLSII LVKERLPHVI
     301  ENSKDGESRW RYILRVYILQ CFDAKAFLDM KYLFCVLGTV FSELSINSAL
     351  TYYGSYATSH GISANDAYTL IMIINVCGIP GRWVPGYLSD KFGRFNVAIA
     401  TLLTLFIVMF VGWLPFGTNL TNMYVISALY GFCSGSVFSL LPVCCGQISK
     451  TEEFGKRYST MYFVVGFGTL VGIPITGAII SIKTTADYQH YIIFCGLATF
     501  VSAVCYIISR AYCVGFKWVR F*

external links for Mch5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY

References cited on this page View Complete Literature Guide for Mch5p

1)	Reihl P and Stolz J (2005) The monocarboxylate transporter homolog Mch5p catalyzes riboflavin (vitamin B2) uptake in Saccharomyces cerevisiae. J Biol Chem 280(48):39809-17
2)	Makuc J, et al. (2001) The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Yeast 18(12):1131-43