ISW2/YOR304W Protein Information Help

Standard Name Isw2p
Systematic Name Yor304wp
ORF Classification Verified
Description ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth (1, 2, 3, 4)
Name Description Imitation SWitch subfamily 1
Experimental Data
Molecules/cell 1520 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,120
Molecular Weight (Da) 130,326
Isoelectric Point (pI) 6.61

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Isw2p (InterPro)
Physical Interactions There are 76 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052F03 | Q08773
MIPS: YOR304W
NCBI: 1420671 | 6324879 | 74676479 | NP_014948.1
GenBank/EMBL/DDBJ: DAA11069.1 | Z75212
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
Amino Acid Sequence (or in FASTA format)
 
       1  MTTQQEEQRS DTKNSKSESP SEVLVDTLDS KSNGSSDDDN IGQSEELSDK
      51  EIYTVEDRPP EYWAQRKKKF VLDVDPKYAK QKDKSDTYKR FKYLLGVTDL
     101  FRHFIGIKAK HDKNIQKLLK QLDSDANKLS KSHSTVSSSS RHHRKTEKEE
     151  DAELMADEEE EIVDTYQEDI FVSESPSFVK SGKLRDYQVQ GLNWLISLHE
     201  NKLSGILADE MGLGKTLQTI SFLGYLRYVK QIEGPFLIIV PKSTLDNWRR
     251  EFLKWTPNVN VLVLHGDKDT RADIVRNIIL EARFDVLITS YEMVIREKNA
     301  LKRLAWQYIV IDEAHRIKNE QSALSQIIRL FYSKNRLLIT GTPLQNNLHE
     351  LWALLNFLLP DIFGDSELFD EWFEQNNSEQ DQEIVIQQLH SVLNPFLLRR
     401  VKADVEKSLL PKIETNVYVG MTDMQIQWYK SLLEKDIDAV NGAVGKREGK
     451  TRLLNIVMQL RKCCNHPYLF EGAEPGPPYT TDEHLIFNSG KMIILDKLLK
     501  RLKEKGSRVL IFSQMSRLLD ILEDYCYFRD FEYCRIDGST SHEERIEAID
     551  EYNKPNSEKF VFLLTTRAGG LGINLVTADT VILFDSDWNP QADLQAMDRA
     601  HRIGQKKQVH VYRFVTENAI EEKVIERAAQ KLRLDQLVIQ QGTGKKTASL
     651  GNSKDDLLDM IQFGAKNMFE KKASKVTVDA DIDDILKKGE QKTQELNAKY
     701  QSLGLDDLQK FNGIENQSAY EWNGKSFQKK SNDKVVEWIN PSRRERRREQ
     751  TTYSVDDYYK EIIGGGSKSA SKQTPQPKAP RAPKVIHGQD FQFFPKELDA
     801  LQEKEQLYFK KKVNYKVTSY DITGDIRNEG SDAEEEEGEY KNAANTEGHK
     851  GHEELKRRIE EEQEKINSAP DFTQEDELRK QELISKAFTN WNKRDFMAFI
     901  NACAKYGRDD MENIKKSIDS KTPEEVEVYA KIFWERLKEI NGWEKYLHNV
     951  ELGEKKNEKL KFQETLLRQK IEQCKHPLHE LIIQYPPNNA RRTYNTLEDK
    1001  FLLLAVNKYG LRADKLYEKL KQEIMMSDLF TFDWFIKTRT VHELSKRVHT
    1051  LLTLIVREYE QPDANKKKRS RTSATREDTP LSQNESTRAS TVPNLPTTMV
    1101  TNQKDTNDHV DKRTKIDQEA *

external links for Isw2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Isw2p
1) Tsukiyama T, et al.  (1999) Characterization of the imitation switch subfamily of ATP-dependent chromatin-remodeling factors in Saccharomyces cerevisiae. Genes Dev 13(6):686-97
2) Gelbart ME, et al.  (2001) Interactions of Isw2 chromatin remodeling complex with nucleosomal arrays: analyses using recombinant yeast histones and immobilized templates. Mol Cell Biol 21(6):2098-106
3) Ruiz C, et al.  (2003) Cell-type-dependent repression of yeast a-specific genes requires Itc1p, a subunit of the Isw2p-Itc1p chromatin remodelling complex. Microbiology 149(Pt 2):341-51
4) Fischer CJ, et al.  (2009) Kinetic mechanism for single-stranded DNA binding and translocation by Saccharomyces cerevisiae Isw2. Biochemistry 48(13):2960-8
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41