TIM18/YOR297C Protein Information

Standard Name	Tim18p 1, 2
Systematic Name	Yor297cp
ORF Classification	Verified
Description	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex (1, 2, 3)
Name Description	Translocase of the Inner Mitochondrial membrane 2

Experimental Data
Molecules/cell	4440 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	192
Molecular Weight (Da)	21,972
Isoelectric Point (pI)	9.12

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tim18p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 24 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0001779C8B \| Q08749 MIPS: YOR297C NCBI: 1420658 \| 347595725 \| 398366137 \| 6470297 \| NP_014940.4 GenBank/EMBL/DDBJ: DAA11062.2 \| AF200324 \| Z75205

Amino Acid Sequence (or in FASTA format)
1 MLLFPGLKPV LNASTVIVNP VRAVFPGLVL STKRSFYSIN RLNAENKIND 51 IANTSKEASS SVQMFKPPEF SQFKDSYQKD YERIAKYTLI PLTMVPFYAS 101 FTGGVINPLL DASLSSIFLI YLQYGFTSCI IDYIPKEKYP RWHKLALYCL 151 YGGSMLSLYG IYELETKNNG FVDLVKKLWN ENDDHLYIFG RN*

Amino Acid Sequence (or in FASTA format)

       1  MLLFPGLKPV LNASTVIVNP VRAVFPGLVL STKRSFYSIN RLNAENKIND
      51  IANTSKEASS SVQMFKPPEF SQFKDSYQKD YERIAKYTLI PLTMVPFYAS
     101  FTGGVINPLL DASLSSIFLI YLQYGFTSCI IDYIPKEKYP RWHKLALYCL
     151  YGGSMLSLYG IYELETKNNG FVDLVKKLWN ENDDHLYIFG RN*

external links for Tim18p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Tim18p

1)	Kerscher O, et al. (2000) Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane. Mol Biol Cell 11(1):103-16
2)	Koehler CM, et al. (2000) Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane. Mol Cell Biol 20(4):1187-93
3)	Rehling P, et al. (2003) Insertion of hydrophobic membrane proteins into the inner mitochondrial membrane--a guided tour. J Mol Biol 326(3):639-57
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41