YPK9/YOR291W Protein Information Help

Standard Name Ypk9p 1
Systematic Name Yor291wp
ORF Classification Verified
Description Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome (1, 2, 3, 4)
Name Description Yeast PARK9 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,472
Molecular Weight (Da) 166,748
Isoelectric Point (pI) 6.06

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ypk9p (InterPro)
Transmembrane Domains There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 1 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012620B | Q12697
MIPS: YOR291W
NCBI: 1420646 | 2493012 | 6324865 | NP_014934.1 | NM_001183710.1
GenBank/EMBL/DDBJ: DAA11055.1 | Z75199
External Classifications EC: 3.6.3.- [Hydrolases, Acting on acid anhydrides; catalysing transmembrane movement of substances]
Amino Acid Sequence (or in FASTA format)
 
       1  MDIPSSNQIQ HGQRSERNRR MPRASFSSTA TTSTAATLTS AMVLDQNNSE
      51  PYAGATFEAV PSSIVSFHHP HSFQSSNLPS PHSSGNLEQR GRRLTESEPL
     101  VLSSAEQSRS SSRNPSHFRF FTQEQISNAE GASTLENTDY DMAWDATPAY
     151  EQDRIYGTGL SSRRSSIRSF SRASSLSNAK SYGSFSKRGR SGSRAPQRLG
     201  ENSDTGFVYH SATHSSSSLS RYTTRERIPI ELESQTDEIL EDESSTHSLE
     251  SSDSRRSASE NNRGSFSGHD DVHNQHSEYL KPDYHEKFYP QYAPNLHYQR
     301  FYIAEEDLVI GIAAYQTSKF WYIIYNLCCF LTFGLVYLLT RWLPHLKVKL
     351  YGVKVPLAKA EWVVIENEFG EFVIQPIDRQ WYNRPLSTVL PFENYPNPSY
     401  EPNDINLSHH HANEINPNVP ILITFEYRYI KFIYSPLDDL FKTNNNWIDP
     451  DWVDLSTVSN GLTKGVQEDR ELAFGKNQIN LRMKTTSEIL FNEVLHPFYV
     501  FQVFSIILWG IDEYYYYAAC IFLISVLSIF DSLNEQKKVS RNLAEMSHFH
     551  CDVRVLRDKF WTTISSSELV PGDIYEVSDP NITILPCDSI LLSSDCIVNE
     601  SMLTGESVPV SKFPATEETM YQLCDDFQST QISSFVSKSF LYNGTNIIRA
     651  RIAPGQTAAL AMVVRTGFST TKGSLVRSMV FPKPTGFKFY RDSFKYIGFM
     701  SLIAIFGFCV SCVQFIKLGL DKKTMILRAL DIITIVVPPA LPATLTIGTN
     751  FALSRLKEKG IFCISPTRLN ISGKIDVMCF DKTGTLTEDG LDVLGVQISE
     801  PNGVRGQKFG ELLSDIRQVF PKFSLNDCSS PLDFKSRNFF MSLLTCHSLR
     851  SVDGNLLGDP LDFKMFQFTG WSFEEDFQKR AFHSLYEGRH EDDVFPENSE
     901  IIPAVVHPDS NNRENTFTDN DPHNFLGVVR SFEFLSELRR MSVIVKTNND
     951  DVYWSFTKGA PEVISEICNK STLPADFEEV LRCYTHNGYR VIACAGKTLP
    1001  KRTWLYSQKV SREEVESNLE FLGFIIFQNK LKKETSETLK SLQDANIRTI
    1051  MCTGDNILTA ISVGREAGLI QCSRVYVPSI NDTPLHGEPV IVWRDVNEPD
    1101  KILDTKTLKP VKLGNNSVES LRECNYTLAV SGDVFRLLFR DENEIPEEYL
    1151  NEILLNSSIY ARMSPDEKHE LMIQLQKLDY TVGFCGDGAN DCGALKAADV
    1201  GISLSEAEAS VAAPFTSKIF NISCVLDVIR EGRAALVTSF ACFQYMSLYS
    1251  AIQFITITIL YSRGSNLGDF QFLYIDLLLI VPIAICMSWS KSYEKIDKKR
    1301  PSANLVSPKI LVPLLISVFL VFLFQFIPWI IVQKMSWYIK PIVGGDDAVQ
    1351  SSDNTVLFFV SNFQYILTAI VLSVGPPYRE PMSKNFEFIV DITVSIGASL
    1401  LLMTLDTESY LGKMLQLTPI SNSFTMFIIV WVILNYYAQL YIPPSIKGWL
    1451  KKKKSSKKYK LLIQEEMKLK EV*

external links for Ypk9p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Ypk9p
1) Gitler AD, et al.  (2009) Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet 41(3):308-15
2) Cronin SR, et al.  (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28
3) Catty P, et al.  (1997) The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. FEBS Lett 409(3):325-32
4) Schmidt K, et al.  (2009) Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2. Biochem Biophys Res Commun 383(2):198-202