SNF2/YOR290C Protein Information Help

Standard Name Snf2p 1, 2
Systematic Name Yor290cp
Alias Gam1p 3 , Haf1p 4 , Swi2p 5 , Tye3p 6, 7
ORF Classification Verified
Description Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p (8, 9)
Name Description Sucrose NonFermenting 1, 10
Experimental Data
Molecules/cell 217 11
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,703
Molecular Weight (Da) 194,050
Isoelectric Point (pI) 6.99

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Snf2p (InterPro)
Physical Interactions There are 202 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052F49 | P22082
MIPS: YOR290C
NCBI: 1279713 | 134589 | 1420644 | 172632 | 2326823 | 398366101 | 449802689 | 4500 | 806532 | NP_014933.3
GenBank/EMBL/DDBJ: DAA11054.1 | D90459 | M61703 | X57837 | X89633 | Z75198 | Z75199
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
Amino Acid Sequence (or in FASTA format)
 
       1  MNIPQRQFSN EEVNRCYLRW QHLRNEHGMN APSVPEFIYL TKVLQFAAKQ
      51  RQELQMQRQQ QGISGSQQNI VPNSSDQAEL PNNASSHISA SASPHLAPNM
     101  QLNGNETFST SAHQSPIMQT QMPLNSNGGN NMLPQRQSSV GSLNATNFSP
     151  TPANNGENAA EKPDNSNHNN LNLNNSELQP QNRSLQEHNI QDSNVMPGSQ
     201  INSPMPQQAQ MQQAQFQAQQ AQQAQQAQQA QQAQARLQQG RRLPMTMFTA
     251  EQSELLKAQI TSLKCLVNRK PIPFEFQAVI QKSINHPPDF KRMLLSLSEF
     301  ARRRQPTDQN NQSNLNGGNN TQQPGTNSHY NNTNTDNVSG LTRNAPLDSK
     351  DENFASVSPA GPSSVHNAKN GTLDKNSQTV SGTPITQTES KKEENETISN
     401  VAKTAPNSNK THTEQNNPPK PQKPVPLNVL QDQYKEGIKV VDIDDPDMMV
     451  DSFTMPNISH SNIDYQTLLA NSDHAKFTIE PGVLPVGIDT HTATDIYQTL
     501  IALNLDTTVN DCLDKLLNDE CTESTRENAL YDYYALQLLP LQKAVRGHVL
     551  QFEWHQNSLL TNTHPNFLSK IRNINVQDAL LTNQLYKNHE LLKLERKKTE
     601  AVARLKSMNK SAINQYNRRQ DKKNKRLKFG HRLIATHTNL ERDEQKRAEK
     651  KAKERLQALK ANDEEAYIKL LDQTKDTRIT HLLRQTNAFL DSLTRAVKDQ
     701  QKYTKEMIDS HIKEASEEVD DLSMVPKMKD EEYDDDDDNS NVDYYNVAHR
     751  IKEDIKKQPS ILVGGTLKDY QIKGLQWMVS LFNNHLNGIL ADEMGLGKTI
     801  QTISLLTYLY EMKNIRGPYL VIVPLSTLSN WSSEFAKWAP TLRTISFKGS
     851  PNERKAKQAK IRAGEFDVVL TTFEYIIKER ALLSKVKWVH MIIDEGHRMK
     901  NAQSKLSLTL NTHYHADYRL ILTGTPLQNN LPELWALLNF VLPKIFNSVK
     951  SFDEWFNTPF ANTGGQDKIE LSEEETLLVI RRLHKVLRPF LLRRLKKDVE
    1001  KELPDKVEKV VKCKMSALQQ IMYQQMLKYR RLFIGDQNNK KMVGLRGFNN
    1051  QIMQLKKICN HPFVFEEVED QINPTRETND DIWRVAGKFE LLDRILPKLK
    1101  ATGHRVLIFF QMTQIMDIME DFLRYINIKY LRLDGHTKSD ERSELLRLFN
    1151  APDSEYLCFI LSTRAGGLGL NLQTADTVII FDTDWNPHQD LQAQDRAHRI
    1201  GQKNEVRILR LITTNSVEEV ILERAYKKLD IDGKVIQAGK FDNKSTSEEQ
    1251  EALLRSLLDA EEERRKKRES GVEEEEELKD SEINEILARN DEEMAVLTRM
    1301  DEDRSKKEEE LGVKSRLLEK SELPDIYSRD IGAELKREES ESAAVYNGRG
    1351  ARERKTATYN DNMSEEQWLR QFEVSDDEKN DKQARKQRTK KEDKSEAIDG
    1401  NGEIKGENID ADNDGPRINN ISAEDRADTD LAMNDDDFLS KKRKAGRPRG
    1451  RPKKVKLEGS ENSEPPALES SPVTGDNSPS EDFMDIPKPR TAGKTSVKSA
    1501  RTSTRGRGRG RGRGRGRGRG RGRPPKARNG LDYVRTPAAA TSPIDIREKV
    1551  AKQALDLYHF ALNYENEAGR KLSDIFLSKP SKALYPDYYM IIKYPVAFDN
    1601  INTHIETLAY NSLKETLQDF HLIFSNARIY NTEGSVVYED SLELEKVVTK
    1651  KYCEIMGDNS QLDFTEFDEQ YGTRPLVLPP VVTSSVAESF TDEADSSMTE
    1701  ASV*

external links for Snf2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Snf2p
1) Neigeborn L and Carlson M  (1984) Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae. Genetics 108(4):845-58
2) Abrams E, et al.  (1986) Molecular analysis of SNF2 and SNF5, genes required for expression of glucose-repressible genes in Saccharomyces cerevisiae. Mol Cell Biol 6(11):3643-51
3) Foury F and Goffeau A  (1979) Genetic control of enhanced mutability of mitochondrial DNA and gamma-ray sensitivity in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(12):6529-33
4) Kuchin SV, et al.  (1993) Genes required for derepression of an extracellular glucoamylase gene, STA2, in the yeast Saccharomyces. Yeast 9(5):533-41
5) Stern M, et al.  (1984) Five SWI genes are required for expression of the HO gene in yeast. J Mol Biol 178(4):853-68
6) Ciriacy M, et al.  (1991) Characterization of trans-acting mutations affecting Ty and Ty-mediated transcription in Saccharomyces cerevisiae. Curr Genet 20(6):441-8
7) Ciriacy M and Williamson VM  (1981) Analysis of mutations affecting Ty-mediated gene expression in Saccharomyces cerevisiae. Mol Gen Genet 182(1):159-63
8) Laurent BC, et al.  (1993) The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation. Genes Dev 7(4):583-91
9) Peterson CL and Tamkun JW  (1995) The SWI-SNF complex: a chromatin remodeling machine? Trends Biochem Sci 20(4):143-6
10) Carlson M, et al.  (1981) Mutants of yeast defective in sucrose utilization. Genetics 98(1):25-40
11) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41