MPD1/YOR288C Protein Information

Standard Name	Mpd1p
Systematic Name	Yor288cp
ORF Classification	Verified
Description	Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation (1, 2, 3)

Experimental Data
Molecules/cell	830 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	318
Molecular Weight (Da)	36,408
Isoelectric Point (pI)	10.41

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mpd1p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 12 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012F45D \| Q12404 MIPS: YOR288C NCBI: 1040701 \| 1279711 \| 1420640 \| 211939363 \| 211939364 \| 2501204 \| 398366089 \| NP_014931.3 \| NM_001183707.3 GenBank/EMBL/DDBJ: DAA11052.1 \| D34633 \| X89633 \| Z75196
External Classifications	EC: 5.3.4.1 [Protein disulfide-isomerase]

Amino Acid Sequence (or in FASTA format)
1 MLFLNIIKLL LGLFIMNEVK AQNFYDSDPH ISELTPKSFD KAIHNTNYTS 51 LVEFYAPWCG HCKKLSSTFR KAAKRLDGVV QVAAVNCDLN KNKALCAKYD 101 VNGFPTLMVF RPPKIDLSKP IDNAKKSFSA HANEVYSGAR TLAPIVDFSL 151 SRIRSYVKKF VRIDTLGSLL RKSPKLSVVL FSKQDKISPV YKSIALDWLG 201 KFDFYSISNK KLKQLTDMNP TYEKTPEIFK YLQKVIPEQR QSDKSKLVVF 251 DADKDKFWEY EGNSINKNDI SKFLRDTFSI TPNEGPFSRR SEYIAYLKTG 301 KKPIKKNHSS SGNKHDEL*

Amino Acid Sequence (or in FASTA format)

       1  MLFLNIIKLL LGLFIMNEVK AQNFYDSDPH ISELTPKSFD KAIHNTNYTS
      51  LVEFYAPWCG HCKKLSSTFR KAAKRLDGVV QVAAVNCDLN KNKALCAKYD
     101  VNGFPTLMVF RPPKIDLSKP IDNAKKSFSA HANEVYSGAR TLAPIVDFSL
     151  SRIRSYVKKF VRIDTLGSLL RKSPKLSVVL FSKQDKISPV YKSIALDWLG
     201  KFDFYSISNK KLKQLTDMNP TYEKTPEIFK YLQKVIPEQR QSDKSKLVVF
     251  DADKDKFWEY EGNSINKNDI SKFLRDTFSI TPNEGPFSRR SEYIAYLKTG
     301  KKPIKKNHSS SGNKHDEL*

external links for Mpd1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Mpd1p

1)	Tachikawa H, et al. (1995) Isolation and characterization of a yeast gene, MPD1, the overexpression of which suppresses inviability caused by protein disulfide isomerase depletion. FEBS Lett 369(2-3):212-6
2)	Norgaard P, et al. (2001) Functional differences in yeast protein disulfide isomerases. J Cell Biol 152(3):553-62
3)	Kimura T, et al. (2005) Interactions among Yeast Protein-Disulfide Isomerase Proteins and Endoplasmic Reticulum Chaperone Proteins Influence Their Activities. J Biol Chem 280(36):31438-41
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41