PLP2/YOR281C Protein Information

Standard Name	Plp2p 1
Systematic Name	Yor281cp
ORF Classification	Verified
Description	Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP (1, 2, 3, 4)
Name Description	Phosducin-Like Protein 1

Experimental Data
Molecules/cell	7700 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	286
Molecular Weight (Da)	32,793
Isoelectric Point (pI)	4.44

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Plp2p (InterPro)
Physical Interactions	There are 21 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000003B3AF \| Q12017 MIPS: YOR281C NCBI: 10716150 \| 1279706 \| 1420627 \| 398366059 \| 45269954 \| 55583863 \| NP_014924.3 GenBank/EMBL/DDBJ: DAA11046.1 \| AF110514 \| AY558032 \| X89633 \| Z75189

Amino Acid Sequence (or in FASTA format)
1 MQNEPMFQVQ VDESEDSEWN DILRAKGVIP ERAPSPTAKL EEALEEAIAK 51 QHENRLEDKD LSDLEELEDD EDEDFLEAYK IKRLNEIRKL QERSKFGEVF 101 HINKPEYNKE VTLASQGKKY EGAQTNDNGE EDDGGVYVFV HLSLQSKLQS 151 RILSHLFQSA ACKFREIKFV EIPANRAIEN YPESNCPTLI VYYRGEVIKN 201 MITLLELGGN NSKMEDFEDF MVKVGAVAEG DNRLIMNRDD EESREERKLH 251 YGEKKSIRSG IRGKFNVGIG GNDDGNINDD DDGFFD*

Amino Acid Sequence (or in FASTA format)

       1  MQNEPMFQVQ VDESEDSEWN DILRAKGVIP ERAPSPTAKL EEALEEAIAK
      51  QHENRLEDKD LSDLEELEDD EDEDFLEAYK IKRLNEIRKL QERSKFGEVF
     101  HINKPEYNKE VTLASQGKKY EGAQTNDNGE EDDGGVYVFV HLSLQSKLQS
     151  RILSHLFQSA ACKFREIKFV EIPANRAIEN YPESNCPTLI VYYRGEVIKN
     201  MITLLELGGN NSKMEDFEDF MVKVGAVAEG DNRLIMNRDD EESREERKLH
     251  YGEKKSIRSG IRGKFNVGIG GNDDGNINDD DDGFFD*

external links for Plp2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Plp2p

1)	Flanary PL, et al. (2000) Functional analysis of Plp1 and Plp2, two homologues of phosducin in yeast. J Biol Chem 275(24):18462-9
2)	Lopez P, et al. (2003) A novel germ line-specific gene of the phosducin-like protein (PhLP) family. A meiotic function conserved from yeast to mice. J Biol Chem 278(3):1751-7
3)	Dekker C, et al. (2008) The interaction network of the chaperonin CCT. EMBO J 27(13):1827-39
4)	McCormack EA, et al. (2009) Yeast phosducin-like protein 2 acts as a stimulatory co-factor for the folding of actin by the chaperonin CCT via a ternary complex. J Mol Biol 391(1):192-206
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41