YTM1/YOR272W Protein Information

Standard Name	Ytm1p 1
Systematic Name	Yor272wp
ORF Classification	Verified
Description	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats (2, 3, 4)

Experimental Data
Molecules/cell	6670 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	460
Molecular Weight (Da)	51,358
Isoelectric Point (pI)	6.95

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ytm1p (InterPro)
Physical Interactions	There are 169 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000005311A \| Q12024 MIPS: YOR272W NCBI: 1279699 \| 1420610 \| 1928989 \| 2494905 \| 398366023 \| NP_014915.3 GenBank/EMBL/DDBJ: DAA11038.1 \| U92821 \| X89633 \| Z75180

Amino Acid Sequence (or in FASTA format)
1 MTEDKSQVKI RFFTREKDEL LHVQDTPMYA PISLKRYGLS EIVNHLLGSE 51 KPVPFDFLIE GELLRTSLHD YLTKKGLSSE ASLNVEYTRA ILPPSYLNSF 101 SNEDWVSSLD VGDGSKHIIS GSYDGIVRTW DLSGNVQKQY SGHSGPIRAV 151 KYISNTRLVS AGNDRTLRLW KTKNDDLKLT SQQQAQEDDD DEVNIEDGKT 201 LAILEGHKAP VVSIDVSDNS RILSASYDNS IGFWSTIYKE MTVVDPLEDI 251 NNPNNKISTA ARKRRKLTMK DGTIRRRAPL SLLESHTAPV EQVIFDSTDN 301 TVGYSVSQDH TIKTWDLVTA RCIDTRTTSY SLLSIAQLST LNLLACGSSA 351 RHITLHDPRV GASSKVTQQQ LIGHKNFVSS LDTCPENEYI LCSGSHDGTV 401 KVWDVRSTSP MYTITREDKS VQKGVNDKVF AVKWAEKVGI ISAGQDKKIQ 451 INKGDNIFKN *

Amino Acid Sequence (or in FASTA format)

       1  MTEDKSQVKI RFFTREKDEL LHVQDTPMYA PISLKRYGLS EIVNHLLGSE
      51  KPVPFDFLIE GELLRTSLHD YLTKKGLSSE ASLNVEYTRA ILPPSYLNSF
     101  SNEDWVSSLD VGDGSKHIIS GSYDGIVRTW DLSGNVQKQY SGHSGPIRAV
     151  KYISNTRLVS AGNDRTLRLW KTKNDDLKLT SQQQAQEDDD DEVNIEDGKT
     201  LAILEGHKAP VVSIDVSDNS RILSASYDNS IGFWSTIYKE MTVVDPLEDI
     251  NNPNNKISTA ARKRRKLTMK DGTIRRRAPL SLLESHTAPV EQVIFDSTDN
     301  TVGYSVSQDH TIKTWDLVTA RCIDTRTTSY SLLSIAQLST LNLLACGSSA
     351  RHITLHDPRV GASSKVTQQQ LIGHKNFVSS LDTCPENEYI LCSGSHDGTV
     401  KVWDVRSTSP MYTITREDKS VQKGVNDKVF AVKWAEKVGI ISAGQDKKIQ
     451  INKGDNIFKN *

external links for Ytm1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ytm1p

1)	Matsumoto, S. and Yahara, I., (1997) YTM1, a suppressor of beta-tubulin mutation, encodes a novel microtubule-interacting protein and is essential for G1/S transition in Saccharomyces cerevisiae. Unpublished
2)	Harnpicharnchai P, et al. (2001) Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8(3):505-15
3)	Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27
4)	Miles TD, et al. (2005) Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes. Mol Cell Biol 25(23):10419-32
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41