HRK1/YOR267C Protein Information Help

Standard Name Hrk1p 1
Systematic Name Yor267cp
ORF Classification Verified
Description Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress (1, 2)
Name Description Hygromycin Resistance Kinase 1
Experimental Data
Molecules/cell 300 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 759
Molecular Weight (Da) 85,695
Isoelectric Point (pI) 7.28

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hrk1p (InterPro)
Physical Interactions There are 74 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004F96D | Q08732
MIPS: YOR267C
NCBI: 1279695 | 1420600 | 2326821 | 59799591 | 6324841 | NP_014910.1 | NM_001183686.1
GenBank/EMBL/DDBJ: DAA11033.1 | X89633 | Z75175 | Z75176
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MPNLLSRNPF HGHHNDHHHD RENSSNNPPQ LIRSSKSFLN FIGRKQSNDS
      51  LRSEKSTDSM KSTTTTTNYT TTNLNNNTHS HSNATSISTN NYNNNYETNH
     101  HHNISHGLHD YTSPASPKQT HSMAELKRFF RPSVNKKLSM SQLRSKKHST
     151  HSPPPSKSTS TVNLNNHYRA QHPHGFTDHY AHTQSAIPPS TDSILSLSNN
     201  INIYHDDCIL AQKYGKLGKL LGSGAGGSVK VLVRPTDGAT FAVKEFRPRK
     251  PNESVKEYAK KCTAEFCIGS TLHHPNVIET VDVFSDSKQN KYYEVMEYCP
     301  IDFFAVVMTG KMSRGEINCC LKQLTEGVKY LHSMGLAHRD LKLDNCVMTS
     351  QGILKLIDFG SAVVFRYPFE DGVTMAHGIV GSDPYLAPEV ITSTKSYDPQ
     401  CVDIWSIGII YCCMVLKRFP WKAPRDSDDN FRLYCMPDDI EHDYVESARH
     451  HEELLKERKE KRQRFLNHSD CSAINQQQPA HESNLKTVQN QVPNTPASIQ
     501  GKSDNKPDIV EEETEENKED DSNNDKESTP DNDKESTIDI KISKNENKST
     551  VVSANPKKVD ADADADCDAN GDSNGRVDCK ANSDCNDKTD CNANNDCSNE
     601  SDCNAKVDTN VNTAANANPD MVPQNNPQQQ QQQQQQQQQQ QQQQQQQHHH
     651  HQHQNQDKAH SIASDNKSSQ QHRGPHHKKI IHGPYRLLRL LPHASRPIMS
     701  RILQVDPKKR ATLDDIFNDE WFAAIAACTM DSKNKVIRAP GHHHTLVREE
     751  NAHLETYKV*

external links for Hrk1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Hrk1p
1) Goossens A, et al.  (2000) Regulation of yeast H(+)-ATPase by protein kinases belonging to a family dedicated to activation of plasma membrane transporters. Mol Cell Biol 20(20):7654-61
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41