GCD1/YOR260W Protein Information Help

Standard Name Gcd1p 1
Systematic Name Yor260wp
Alias Tra3p 2
ORF Classification Verified
Description Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression (3, 4)
Name Description General Control Derepressed 5
Experimental Data
Molecules/cell 9530 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 578
Molecular Weight (Da) 65,699
Isoelectric Point (pI) 4.63

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gcd1p (InterPro)
Physical Interactions There are 105 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530C5 | P09032
MIPS: YOR260W
NCBI: 1420587 | 2506383 | 3732 | 6324834 | NP_014903.1 | NM_001183679.1
GenBank/EMBL/DDBJ: DAA11027.1 | X07846 | Z75168
Amino Acid Sequence (or in FASTA format)
 
       1  MSIQAFVFCG KGSNLAPFTQ PDFPFQTQNK DSTAATSGDK LNELVNSALD
      51  STVINEFMQH STRLPKALLP IGNRPMIEYV LDWCDQADFK EISVVAPVDE
     101  IELIESGLTS FLSLRKQQFE LIYKALSNSN HSHHLQDPKK INFIPSKANS
     151  TGESLQKELL PRINGDFVIL PCDFVTDIPP QVLVDQFRNR DDNNLAMTIY
     201  YKNSLDSSID KKQQQKQKQQ QFFTVYSENE DSERQPILLD VYSQRDVTKT
     251  KYLQIRSHLL WNYPNLTVST KLLNSFIYFC SFELCQLLKL GPQSMSRQAS
     301  FKDPFTGNQQ QQNPPTTDDD EDRNHDDDDD YKPSATSIQP TYFKKKNDLI
     351  LDPINCNKSL SKVFRDLSRR SWQHSKPREP IGIFILPNET LFIRANNLNA
     401  YMDANRFVLK IKSQTMFTKN IQIQSAAIGA DAIVDPKCQI SAHSNVKMSV
     451  LGTQANIGSR CRVAGSLLFP GVHLGDEVIL ENCIIGPMAK IGSKCKLSNC
     501  YIEGHYVVEP KNNFKGETLA NVYLDEDEED ELIYDDSVIA GESEIAEETD
     551  SDDRSDEDSD DSEYTDEYEY EDDGLFER*

external links for Gcd1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Gcd1p
1) Yep, D.  (1973) Ph.D. Thesis, Cornell University, Ithaca, N.Y
2) Wolfner M, et al.  (1975) Integration of amino acid biosynthesis into the cell cycle of Saccharomyces cerevisiae. J Mol Biol 96(2):273-90
3) Pavitt GD, et al.  (1998) eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange. Genes Dev 12(4):514-26
4) Hinnebusch A  (1992) "General and Pathway-specific Regulatory Mechanisms Controlling the Synthesis of Amino Acid Biosynthetic Enzymes in Saccharomyces cerevisiae". Pp. 319-414 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
5) Lucchini G, et al.  (1984) Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae. Mol Cell Biol 4(7):1326-33
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41