RPT4/YOR259C Protein Information Help

Standard Name Rpt4p 1, 2
Systematic Name Yor259cp
Alias Crl13p , Pcs1p , Sug2p
ORF Classification Verified
Description ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization (3, 4, 5, 6, 7)
Name Description Regulatory Particle Triple-A protein, or Regulatory Particle Triphosphatase 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 437
Molecular Weight (Da) 49,408
Isoelectric Point (pI) 5.54

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rpt4p (InterPro)
Physical Interactions There are 162 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000531AA | P53549
MIPS: YOR259C
NCBI: 1147800 | 1420585 | 1931623 | 2506090 | 398365977 | NP_014902.3 | NM_001183678.3
GenBank/EMBL/DDBJ: AAA85134.1 | AAB51594.1 | CAA99481.1 | DAA11026.1 | U43720 | U93262 | Z75167
Amino Acid Sequence (or in FASTA format)
       1  MSEEQDPLLA GLGETSGDNH TQQSHEQQPE QPQETEEHHE EEPSRVDPEQ
      51  EAHNKALNQF KRKLLEHRRY DDQLKQRRQN IRDLEKLYDK TENDIKALQS
     101  IGQLIGEVMK ELSEEKYIVK ASSGPRYIVG VRNSVDRSKL KKGVRVTLDI
     151  TTLTIMRILP RETDPLVYNM TSFEQGEITF DGIGGLTEQI RELREVIELP
     201  LKNPEIFQRV GIKPPKGVLL YGPPGTGKTL LAKAVAATIG ANFIFSPASG
     251  IVDKYIGESA RIIREMFAYA KEHEPCIIFM DEVDAIGGRR FSEGTSADRE
     301  IQRTLMELLT QMDGFDNLGQ TKIIMATNRP DTLDPALLRP GRLDRKVEIP
     351  LPNEAGRLEI FKIHTAKVKK TGEFDFEAAV KMSDGFNGAD IRNCATEAGF
     401  FAIRDDRDHI NPDDLMKAVR KVAEVKKLEG TIEYQKL*             

external links for Rpt4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Aspergillus (AspGD) CYC2008 (complexes) MIPS YPL+
Candida (CGD) Complexome Pfam domains YeastGFP
YGOB DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository
YOGY GeneMANIA


IMP


YeastRC Mass Spec (Seattle)


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rpt4p
1) Finley D, et al.  (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2) McCusker, J.H. and J.E. Haber  (1996) SUG2 {crl13} is identical to CRL13. Personal Communication
3) Glickman MH, et al.  (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol 18(6):3149-62
4) McDonald HB and Byers B  (1997) A proteasome cap subunit required for spindle pole body duplication in yeast. J Cell Biol 137(3):539-53
5) Russell SJ, et al.  (1999) Subcellular localization, stoichiometry, and protein levels of 26 S proteasome subunits in yeast. J Biol Chem 274(31):21943-52
6) Rubin DM, et al.  (1998) Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome. EMBO J 17(17):4909-19
7) Lipson C, et al.  (2008) A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates. J Biol Chem 283(11):7166-75