KIN4/YOR233W Protein Information Help

Standard Name Kin4p
Systematic Name Yor233wp
Alias Kin31p , Kin3p 1
ORF Classification Verified
Description Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description KINase 1, 6
Experimental Data
Molecules/cell 143 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 800
Molecular Weight (Da) 90,087
Isoelectric Point (pI) 10.3

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Kin4p (InterPro)
Physical Interactions There are 56 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012DE66 | Q01919
MIPS: YOR233W
NCBI: 1420535 | 5515 | 6324807 | 729900 | NP_014876.1
GenBank/EMBL/DDBJ: DAA11003.1 | X67916 | Z75141
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MASVPKRHTY GGNVVTDRDR HSLQRNNEIL HPIHKNQRKH ATFGPYIIGS
      51  TLGEGEFGKV KLGWTKASSS NEVPKQVAIK LIRRDTIKKD ADKEIKIYRE
     101  INALKHLTHP NIIYLEEVLQ NSKYIGIVLE FVSGGEFYKY IQRKRRLKES
     151  SACRLFAQLI SGVNYMHYKG LVHRDLKLEN LLLDKHENLV ITDFGFVNEF
     201  FEDNELMKTS CGSPCYAAPE LVVSTKAYEA RKADVWSCGV ILYAMLAGYL
     251  PWDDDHENPT GDDIARLYKY ITQTPLKFPE YITPIPRDLL RRILVPNPRR
     301  RINLQTIKRH VWLKPHEAFL SIQPNYWDEH LQKERPKPPN KGDVGRHSTY
     351  SSSASSYSKS RDRNSLIIES TLEQHRMSPQ LATSRPASPT FSTGSKVVLN
     401  DTKNDMKESN INGERTSASC RYTRDSKGNG QTQIEQVSAR HSSRGNKHTS
     451  VAGLVTIPGS PTTARTRNAP SSKLTEHVKD SSQTSFTQEE FHRIGNYHVP
     501  RSRPRPTSYY PGLSRNTADN SLADIPVNKL GSNGRLTDAK DPVPLNAIHD
     551  TNKATISNNS IMLLSEGPAA KTSPVDYHYA IGDLNHGDKP ITEVIDKINK
     601  DLTHKAAENG FPRESIDPES TSTILVTKEP TNSTDEDHVE SQLENVGHSS
     651  NKSDASSDKD SKKIYEKKRF SFMSLYSSLN GSRSTVESRT SKGNAPPVSS
     701  RNPSGQSNRS NIKITQQQPR NLSDRVPNPD KKINDNRIRD NAPSYAESEN
     751  PGRSVRASVM VSTLREENRS ELSNEGNNVE AQTSTARKVL NFFKRRSMRV
     801  *

external links for Kin4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Kin4p
1) Kambouris NG, et al.  (1993) Cloning and genetic analysis of the gene encoding a new protein kinase in Saccharomyces cerevisiae. Yeast 9(2):141-50
2) Zhu H, et al.  (2000) Analysis of yeast protein kinases using protein chips. Nat Genet 26(3):283-9
3) Pereira G and Schiebel E  (2005) Kin4 kinase delays mitotic exit in response to spindle alignment defects. Mol Cell 19(2):209-21
4) D'Aquino KE, et al.  (2005) The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell 19(2):223-34
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Levin DE, et al.  (1987) Two yeast genes that encode unusual protein kinases. Proc Natl Acad Sci U S A 84(17):6035-9
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41