MGE1/YOR232W Protein Information

Standard Name	Mge1p 1
Systematic Name	Yor232wp
Alias	Yge1p 2
ORF Classification	Verified
Description	Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE (1, 2, 3, 4, 5, 6) Also known as: GRPE 5
Name Description	Mitochondrial GrpE 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	228
Molecular Weight (Da)	26,066
Isoelectric Point (pI)	8.9

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mge1p (InterPro)
Physical Interactions	There are 68 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012BB42 \| P38523 MIPS: YOR232W NCBI: 1420533 \| 398365871 \| 457594 \| 468512 \| 493576 \| 585221 \| NP_014875.3 GenBank/EMBL/DDBJ: DAA11002.1 \| D26059 \| U09565 \| X78350 \| Z75140

Amino Acid Sequence (or in FASTA format)
1 MRAFSAATVR ATTRKSFIPM APRTPFVTPS FTKNVGSMRR MRFYSDEAKS 51 EESKENNEDL TEEQSEIKKL ESQLSAKTKE ASELKDRLLR SVADFRNLQQ 101 VTKKDIQKAK DFALQKFAKD LLESVDNFGH ALNAFKEEDL QKSKEISDLY 151 TGVRMTRDVF ENTLRKHGIE KLDPLGEPFD PNKHEATFEL PQPDKEPGTV 201 FHVQQLGFTL NDRVIRPAKV GIVKGEEN*

Amino Acid Sequence (or in FASTA format)

       1  MRAFSAATVR ATTRKSFIPM APRTPFVTPS FTKNVGSMRR MRFYSDEAKS
      51  EESKENNEDL TEEQSEIKKL ESQLSAKTKE ASELKDRLLR SVADFRNLQQ
     101  VTKKDIQKAK DFALQKFAKD LLESVDNFGH ALNAFKEEDL QKSKEISDLY
     151  TGVRMTRDVF ENTLRKHGIE KLDPLGEPFD PNKHEATFEL PQPDKEPGTV
     201  FHVQQLGFTL NDRVIRPAKV GIVKGEEN*

external links for Mge1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Mge1p

1)	Laloraya S, et al. (1994) A role for a eukaryotic GrpE-related protein, Mge1p, in protein translocation. Proc Natl Acad Sci U S A 91(14):6481-5
2)	Ikeda E, et al. (1994) YGE1 is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions. FEBS Lett 339(3):265-8
3)	Deloche O and Georgopoulos C (1996) Purification and biochemical properties of Saccharomyces cerevisiae's Mge1p, the mitochondrial cochaperone of Ssc1p. J Biol Chem 271(39):23960-6
4)	Miao B, et al. (1997) Mge1 functions as a nucleotide release factor for Ssc1, a mitochondrial Hsp70 of Saccharomyces cerevisiae. J Mol Biol 265(5):541-52
5)	Bolliger L, et al. (1994) A mitochondrial homolog of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viability. EMBO J 13(8):1998-2006
6)	Schmidt S, et al. (2001) The two mitochondrial heat shock proteins 70, Ssc1 and Ssq1, compete for the cochaperone Mge1. J Mol Biol 313(1):13-26