MKK1/YOR231W Protein Information Help

Standard Name Mkk1p 1
Systematic Name Yor231wp
Alias Ssp32p
ORF Classification Verified
Description MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Mitogen-activated protein Kinase-Kinase 1
Experimental Data
Molecules/cell 1040 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 508
Molecular Weight (Da) 56,720
Isoelectric Point (pI) 8.32

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mkk1p (InterPro)
Physical Interactions There are 47 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F195 | P32490
MIPS: YOR231W
NCBI: 1420531 | 218492 | 417302 | 62467575 | 6324805 | NP_014874.1
GenBank/EMBL/DDBJ: DAA11001.1 | AY899252 | D13001 | Z75139
External Classifications EC: 2.7.12.2 [Mitogen-activated protein kinase kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MASLFRPPES AKCNPNSPRL KLPLLRNNQV DENNIYLTSN GSSTTAYSSH
      51  TPEPLTSSTS TLFSQTRLHP SDSSMTLNTM KKRPAPPSLP SLSINSQSKC
     101  KTLPELVPIA DVSDGKHDLG LKQRVIAENE LSGNSDLTPS SMASPFSHTN
     151  TSSPYLRNDL SNSVGSDFSN LISAYEQSSS PIKSSSQPKS SSESYIDLNS
     201  VRDVDQLDEN GWKYANLKDR IETLGILGEG AGGSVSKCKL KNGSKIFALK
     251  VINTLNTDPE YQKQIFRELQ FNRSFQSEYI VRYYGMFTDD ENSSIYIAME
     301  YMGGRSLDAI YKNLLERGGR ISEKVLGKIA EAVLRGLSYL HEKKVIHRDI
     351  KPQNILLNEN GQVKLCDFGV SGEAVNSLAT TFTGTSFYMA PERIQGQPYS
     401  VTSDVWSLGL TILEVANGKF PCSSEKMAAN IAPFELLMWI LTFTPELKDE
     451  PESNIIWSPS FKSFIDYCLK KDSRERPSPR QMINHPWIKG QMKKNVNMEK
     501  FVRKCWKD*

external links for Mkk1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
YGOB CYC2008 (complexes) Pfam domains
YOGY Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Mkk1p
1) Irie K, et al.  (1993) MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Mol Cell Biol 13(5):3076-83
2) Levin DE, et al.  (1994) Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae. Cell Mol Biol Res 40(3):229-39
3) Heinisch JJ, et al.  (1999) The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae. Mol Microbiol 32(4):671-80
4) Soler M, et al.  (1995) Characterization of domains in the yeast MAP kinase Slt2 (Mpk1) required for functional activity and in vivo interaction with protein kinases Mkk1 and Mkk2. Mol Microbiol 17(5):833-42
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41