WTM1/YOR230W Protein Information

Standard Name	Wtm1p 1
Systematic Name	Yor230wp
ORF Classification	Verified
Description	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats (1, 2, 3)
Name Description	WD repeat containing Transcriptional Modulator 1

Experimental Data
Molecules/cell	7750 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	437
Molecular Weight (Da)	48,382
Isoelectric Point (pI)	5.08

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Wtm1p (InterPro)
Physical Interactions	There are 40 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000138FA7 \| Q12363 MIPS: YOR230W NCBI: 1050782 \| 1420529 \| 2160780 \| 2494902 \| 398365853 \| 51013763 \| NP_014873.3 GenBank/EMBL/DDBJ: DAA11000.1 \| AF001451 \| AY693156 \| X92441 \| Z75138

Amino Acid Sequence (or in FASTA format)
1 MPKKVWKSST PSTYEHISSL RPKFVSRVDN VLHQRKSLTF SNVVVPDKKN 51 NTLTSSVIYS QGSDIYEIDF AVPLQEAASE PVKDYGDAFE GIENTSLSPK 101 FVYQGETVSK MAYLDKTGET TLLSMSKNGS LAWFKEGIKV PIHIVQELMG 151 PATSYASIHS LTRPGDLPEK DFSLAISDFG ISNDTETIVK SQSNGDEEDS 201 ILKIIDNAGK PGEILRTVHV PGTTVTHTVR FFDNHIFASC SDDNILRFWD 251 TRTSDKPIWV LGEPKNGKLT SFDCSQVSNN LFVTGFSTGI IKLWDARAAE 301 AATTDLTYRQ NGEDPIQNEI ANFYHAGGDS VVDVQFSATS SSEFFTVGGT 351 GNIYHWNTDY SLSKYNPDDT IAPPQDATEE SQTKSLRFLH KGGSRRSPKQ 401 IGRRNTAAWH PVIENLVGTV DDDSLVSIYK PYTEESE*

Amino Acid Sequence (or in FASTA format)

       1  MPKKVWKSST PSTYEHISSL RPKFVSRVDN VLHQRKSLTF SNVVVPDKKN
      51  NTLTSSVIYS QGSDIYEIDF AVPLQEAASE PVKDYGDAFE GIENTSLSPK
     101  FVYQGETVSK MAYLDKTGET TLLSMSKNGS LAWFKEGIKV PIHIVQELMG
     151  PATSYASIHS LTRPGDLPEK DFSLAISDFG ISNDTETIVK SQSNGDEEDS
     201  ILKIIDNAGK PGEILRTVHV PGTTVTHTVR FFDNHIFASC SDDNILRFWD
     251  TRTSDKPIWV LGEPKNGKLT SFDCSQVSNN LFVTGFSTGI IKLWDARAAE
     301  AATTDLTYRQ NGEDPIQNEI ANFYHAGGDS VVDVQFSATS SSEFFTVGGT
     351  GNIYHWNTDY SLSKYNPDDT IAPPQDATEE SQTKSLRFLH KGGSRRSPKQ
     401  IGRRNTAAWH PVIENLVGTV DDDSLVSIYK PYTEESE*

external links for Wtm1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Wtm1p

1)	Pemberton LF and Blobel G (1997) Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Mol Cell Biol 17(8):4830-41
2)	Zhang Z, et al. (2006) Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proc Natl Acad Sci U S A 103(5):1422-7
3)	Tringe SG, et al. (2006) The WTM Genes in Budding Yeast Amplify Expression of the Stress-Inducible Gene RNR3. Genetics 174(3):1215-28
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41